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Establishment of objective and quantitative therapeutic evaluation method for transcorneal electrical stimulation therapy

Research Project

Project/Area Number 26861439
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionNiigata University

Principal Investigator

Hatase Tetsuhisa  新潟大学, 医歯学総合病院, 医員 (20723943)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords経角膜電気刺激治療 / 外傷性視神経症 / 虚血性視神経症 / RAPDx / 瞳孔記録計RAPDx
Outline of Final Research Achievements

Using RAPDx for refractory optic nerve disease, objective and quantitative therapeutic evaluation of transcorneal electrical stimulation therapy (TES) was performed. The subjects were 5 cases of traumatic optic neuropathy and 9 cases of ischemic optic neuropathy. The amplitude score (AS) and latency score (LS) of RAPDx were measured before treatment and one month after the end of treatment, and statistical analysis was performed using t test for both groups AS and LS before and after treatment. The results showed that there was no statistically significant difference between AS and LS before and after treatment in both groups. For each case, there was one case with traumatic optic nerve cases and two cases with ischemic optic neuropathy in which AS was clearly reduced. It is suggested that TES may be effective even in a few cases, even in objective evaluation.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (15 results)

All 2018 2017 2016 2015 2014

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results)

  • [Journal Article] SS-OCTのEn faceイメージによる視神経部分低形成(SOH)の網膜神経線維束観察(update)2017

    • Author(s)
      飯川 龍, 植木 智志, 畑瀬 哲尚, 栂野 哲哉, 宮本 大輝, 福地 健郎
    • Journal Title

      眼科臨床紀要

      Volume: 10 Pages: 77-78

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 視神経部分低形成では大脳形態異常はみられるか? 14例のMR画像所見2017

    • Author(s)
      福武 慈, 植木 智志, 羽入 貴子, 畑瀬 哲尚, 福地 健郎
    • Journal Title

      眼科臨床紀要

      Volume: 10 Pages: 74-75

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 経過観察中に視機能の著明な改善が見られたAZOORの一例2017

    • Author(s)
      落合 竣, 植木 智志, 畑瀬 哲尚, 福武 慈, 福地 健郎
    • Journal Title

      眼科臨床紀要

      Volume: 10 Pages: 74-74

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acute zonal occult outer retinopathy12例の視力予後および多局所ERG所見と視力の相関2016

    • Author(s)
      落合 竣, 植木 智志, 畑瀬 哲尚, 福武 慈, 福地 健郎
    • Journal Title

      神経眼科

      Volume: 33 Pages: 92-92

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 片眼義眼の僚眼に顕性潜伏眼振がみられた3例2016

    • Author(s)
      植木 智志, 羽入 貴子, 畑瀬 哲尚, 福武 慈, 福地 健郎
    • Journal Title

      眼科臨床紀要

      Volume: 9 Pages: 611-611

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] サルコイドーシスに関連した視神経炎の1例2016

    • Author(s)
      畑瀬 哲尚, 黒澤 史門, 福武 慈, 羽入 貴子, 植木 智志, 福地 健郎
    • Journal Title

      眼科臨床紀要

      Volume: 9 Pages: 610-611

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological features in anterior visual pathway in neuromyelitis optica2016

    • Author(s)
      Hokari M, Yokoseki A, Arakawa M, Saji E, Yanagawa K, Yanagimura F, Toyoshima Y, Okamoto K, Ueki S, Hatase T, Ohashi R, Fukuchi T, Akazawa K, Yamada M, Kakita A, Takahashi H, Nishizawa M, Kawachi I.
    • Journal Title

      Annals of Neurology

      Volume: 79 Issue: 4 Pages: 605-624

    • DOI

      10.1002/ana.24608

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 開瞼失行の1例2015

    • Author(s)
      畑瀬哲尚、植木智志、羽入貴子、福地健郎
    • Journal Title

      眼科臨床紀要

      Volume: 9(2) Pages: 187-187

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 視神経乳頭への転移が疑われた肺腺癌の1例2015

    • Author(s)
      畑瀬哲尚、植木智志、羽入貴子、福地健郎
    • Journal Title

      眼科臨床紀要

      Volume: 8(7) Pages: 527-528

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 眼科健診から専門医を受診した小児の検討2014

    • Author(s)
      石井 雅子, 落合 竣, 松浦 将人, 畑瀬 哲尚, 植木 智志, 羽入 貴子, 福地 健郎
    • Journal Title

      眼科臨床紀要

      Volume: 7 Pages: 131-135

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 難治性視神経症に対する経角膜電気刺激治療のRAPDxを用いた他覚的、定量的治療評価2018

    • Author(s)
      畑瀬哲尚
    • Organizer
      第55回 日本神経眼科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 網膜色素変性の合併が疑われた小口病の一例2016

    • Author(s)
      畑瀬哲尚, 植木智志, 福武慈, 羽入貴子, 福地健郎
    • Organizer
      第54回日本神経眼科学会
    • Place of Presentation
      宮崎市民プラザ(宮崎県宮崎市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 小児の甲状腺眼症の2症例2014

    • Author(s)
      畑瀬哲尚、植木智志、羽入貴子、福地健郎
    • Organizer
      第52回日本神経眼科学会
    • Place of Presentation
      幕張メッセ(千葉県・千葉市)
    • Year and Date
      2014-12-12 – 2014-12-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Anisometropia and anisometropic amblyopia ipsilateral to the ptotic eye in congenital ptosis children。2014

    • Author(s)
      Satoshi Ueki, Yuji Suzuki1, Takako Hanyu, Tetsuhisa Hatase, Takeo Fukuchi
    • Organizer
      ISA 国際斜視学会 2014
    • Place of Presentation
      国立京都国際会館(京都府・京都市)
    • Year and Date
      2014-12-01 – 2014-12-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Three school children with spasm of the near refle2014

    • Author(s)
      Takako Hanyu,Satoshi Ueki,Tetsuhisa Hatase,Takeo Fukuchi
    • Organizer
      ISA 国際斜視学会 2014
    • Place of Presentation
      国立京都国際会館(京都府・京都市)
    • Year and Date
      2014-12-01 – 2014-12-04
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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