| Project/Area Number |
26861462
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Nagata Maho 京都府立医科大学, 医学部附属病院, 後期特定専攻医 (40614102)
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| Research Collaborator |
Fullwood Nigel ランカスター大学, Biomedical and Life Science, Senior Lecturer
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 角膜上皮 / 細胞分化 / 創傷治癒 / 角膜混濁 / Wntシグナル / R-spondin1 / 分化異常 / 新生血管 / 炎症 / Wnt / 角膜 / 細胞間接着 / 細胞増殖 / 幹細胞 |
|---|
| Outline of Final Research Achievements |
R-spondin1 (RSPO1) is a ligand of the Wnt signaling pathway that regulates crucial aspects of cell fate determination such as embryonic development, cell proliferation, and cell differentiation. Role of RSPO1 in corneal homeostasis was investigated. As a result, RSPO1 gene knockout mouse represented subepithelial corneal opacity, delay of corneal epithelial wound healing, and abnormality of corneal differentiation, that indicates the important role of RSPO1 in corneal homeostasis.
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