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Role of R-spondin1 in corneal homeostasis

Research Project

Project/Area Number 26861462
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Nagata Maho  京都府立医科大学, 医学部附属病院, 後期特定専攻医 (40614102)

Research Collaborator Fullwood Nigel  ランカスター大学, Biomedical and Life Science, Senior Lecturer
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords角膜上皮 / 細胞分化 / 創傷治癒 / 角膜混濁 / Wntシグナル / R-spondin1 / 分化異常 / 新生血管 / 炎症 / Wnt / 角膜 / 細胞間接着 / 細胞増殖 / 幹細胞
Outline of Final Research Achievements

R-spondin1 (RSPO1) is a ligand of the Wnt signaling pathway that regulates crucial aspects of cell fate determination such as embryonic development, cell proliferation, and cell differentiation. Role of RSPO1 in corneal homeostasis was investigated. As a result, RSPO1 gene knockout mouse represented subepithelial corneal opacity, delay of corneal epithelial wound healing, and abnormality of corneal differentiation, that indicates the important role of RSPO1 in corneal homeostasis.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (15 results)

All 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (6 results) Book (2 results) Remarks (3 results)

  • [Int'l Joint Research] ランカスター大学(英国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Elevated expression of ABCB5 in ocular surface squamous neoplasia.2016

    • Author(s)
      11.Jongkhajornpong P, Nakamura T, Sotozono C, Nagata M, Inatomi T, Kinoshita S.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 20541-20541

    • DOI

      10.1038/srep20541

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] JBP485 promotes tear and mucin secretion in ocular surface epithelia.2015

    • Author(s)
      9.Nakamura T, Hata Y, Nagata M, Yokoi N, Yamaguchi S, Kaku T, Kinoshita S.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 10248-10248

    • DOI

      10.1038/srep10248

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] JBP485 promotes corneal epithelial wound healing.2015

    • Author(s)
      Nagata M, Nakamura T, Hata Y, Yamaguchi S, Kaku T, Kinoshita S.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 14776-14776

    • DOI

      10.1038/srep14776

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 合成ペプチドJBP485の角膜上皮創傷治癒促進効果2016

    • Author(s)
      永田真帆、中村隆宏、畑友衣子、村越友衣乃、山口俊平、郭太乙、外園千恵、木下茂
    • Organizer
      角膜カンファランス 2016
    • Place of Presentation
      長野県北佐久郡軽井沢町
    • Year and Date
      2016-02-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] ラエンネックによるムチン分泌・産生能に関する検討2016

    • Author(s)
      村越友衣乃、中村隆宏、永田真帆、山口俊平、郭太乙、外園千恵、木下茂
    • Organizer
      角膜カンファランス 2016
    • Place of Presentation
      長野県北佐久郡軽井沢町
    • Year and Date
      2016-02-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヒト角結膜上皮細胞に対するラミニン511の細胞生物学的効果に関する検討2016

    • Author(s)
      岩本美優、中村隆宏、永田真帆、村越友衣乃、奥村直毅、外園千恵、小泉範子、木下茂
    • Organizer
      角膜カンファランス 2016
    • Place of Presentation
      長野県北佐久郡軽井沢町
    • Year and Date
      2016-02-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヒト角膜上皮細胞に対するR-spondin1の機能解析2015

    • Author(s)
      大倉翔貴、中村隆宏、畑由衣子、岩本美優、永田真帆、小泉範子、木下茂
    • Organizer
      角膜カンファランス2015(第39回日本角膜学会総会/第31回日本角膜移植学会)
    • Place of Presentation
      高知市
    • Year and Date
      2015-02-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 角膜上皮創傷治癒におけるR-spondin1の発現解析2015

    • Author(s)
      永田真帆、中村隆宏、畑由衣子、大倉翔貴、岩本美優、木下茂
    • Organizer
      角膜カンファランス2015(第39回日本角膜学会総会/第31回日本角膜移植学会)
    • Place of Presentation
      高知市
    • Year and Date
      2015-02-11 – 2015-02-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 角膜上皮創傷治癒におけるR-spondin1の発現2014

    • Author(s)
      永田真帆、中村隆宏、畑由衣子、大倉翔貴、岩本美優、木下茂
    • Organizer
      4大学連携研究フォーラム
    • Place of Presentation
      京都市
    • Year and Date
      2014-12-05
    • Related Report
      2014 Research-status Report
  • [Book] 小児眼科学2015

    • Author(s)
      東範行
    • Total Pages
      570
    • Publisher
      三輪書店
    • Related Report
      2015 Annual Research Report
  • [Book] 知っておきたい眼腫瘍診療2015

    • Author(s)
      大島 浩一/後藤 浩
    • Total Pages
      476
    • Publisher
      医学書院
    • Related Report
      2015 Annual Research Report
  • [Remarks] 京都府立医科大学眼科/研究実績

    • URL

      http://www.ophth.kpu-m.ac.jp/actual_results/2011/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 京都府立医科大学感覚器未来医療学/教授木下茂/著書・論文

    • URL

      http://shigerukinoshita.com/publications/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] Lancaster University/publications

    • URL

      http://www.research.lancs.ac.uk/portal/en/people/nigel-fullwood(07632a44-c3b1-408f-8753-a7e252e0f9c6)/publications.html

    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2022-01-31  

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