Pathogenesis of proliferative intraocular disease

Research Project

Project/Area Number	26861470
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Ophthalmology
Research Institution	Tokyo Medical University
Principal Investigator	Umazume Kazuhiko 東京医科大学, 医学部, 講師 (80532209)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	増殖硝子体網膜症 / チロシンキナーゼ阻害薬 / ミュラー細胞 / 眼内増殖疾患 / ミューラー細胞 / ダサチニブ / 眼内増殖性疾患
Outline of Final Research Achievements	We investigated pathogenesis of proliferative vitreoretinopathy using muller cells. Muller cell could change phenotype as fibroblast/myofibroblast in 25 vitreous-DMEM as well as RPE cells. Dasatinib,a tyrosine kinase inhibitor, inhibited migration, proliferation and contraction in muller cells.

Report

(4 results)