Mechanism analysis, suppresion of EAON by DC Transfected with PU.1.

Research Project

Project/Area Number	26861471
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Ophthalmology
Research Institution	Tokyo Medical University
Principal Investigator	Matsuda Ryusaku 東京医科大学, 医学部, 兼任講師 (10449209)
Research Collaborator	Umazume Akihiko 東京医科大学, 医学部, 助教 (20617568) Yamakawa Naoyuki 東京医科大学, 医学部, 助教 (80599134)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	PU.1 / EAE / EAON / EAU / 視神経炎 / 遺伝子治療 / pu.1
Outline of Final Research Achievements	In this study, we investigated PU.1 expression in the retina of mice with experimental autoimmune uveoretinitis (EAU) and the association between PU.1 expression level and inflammation in EAU. PU.1 may play crucial roles in the development and progression of inflammation in EAU