| Project/Area Number |
26861495
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Wang Wei 東京医科歯科大学, 生体材料工学研究所, 非常勤講師 (60451944)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 再生医療 / 小口径人口血管 / 生体材料 / 小口径人工血管 / 脱細胞 |
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| Outline of Final Research Achievements |
We tried to develop a highly functional, long-term reliable, off-the-shelf product of small diameter vascular graft for the surgical treatment of ischemic deceases such like cardiac infarct. rat's arteries were harvested, decellularized and anti-coagulation treated for graft use. Through our study, we invented an automatic tissue decellularizing machine with inner and outer double circulation function; we optimized the procedure for vessel decellularization with a combination of SDS and ultrasonic bath; we confirmed the cell affinity of decellularized vessels. We tried lumen immobilization of several anti coagulation substances such like haperin, MPC polymers, long-term patency was not attained. Further experiments of lumen anti coagulation is needed.
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