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Development of noninvasive prophylactic treatment for intervention in the mechanism of development of lymphedema

Research Project

Project/Area Number 26861504
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Plastic surgery
Research InstitutionYokohama City University

Principal Investigator

YABUKI Yuichiro  横浜市立大学, 附属病院, 助教 (30610357)

Research Collaborator MAEGAWA Jiro  
HIROTOMI Koichi  
MATSUBARA Shinobu  
KITAYAMA Shinya  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsリンパ浮腫 / マイクロサージャリー / レニン・アンジオテンシン / 動物モデル / レニン・アンジオテンシン系 / 予防
Outline of Final Research Achievements

We attempted to verify 1) lymphedema model rat and 2) verify the renin / angiotensin system in lymphedema.
1) obvious edema lasted about 1 week in the model rats we created, and histological changes lasted more than 4 weeks. After 16 weeks, histological changes disappeared, and deep lymphatic vessels were expanded. It was suggested that collateral lymph flow was formed in rats and did not result in chronic lymphedema.
2) human lymph duct specimen of chronic lymphedema patient was provided and immuno-histological analysis was done. In part, TNF-α, other angiotensin II receptor, etc. were positive. Inflammatory cytokines and renin / angiotensin system were suggested to be involved in the development of chronic lymphedema.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2016

All Presentation (2 results)

  • [Presentation] 原発性リンパ浮腫についての組織学的検討---その経緯と今後の方向性2016

    • Author(s)
      三上太郎
    • Organizer
      日本形成外科学会基礎学術集会
    • Place of Presentation
      ナレッジキャピタル コングレコンベンションセンター(大阪府)
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 原発性リンパ浮腫および続発性リンパ浮腫における組織形態学的検討2016

    • Author(s)
      平出さおり
    • Organizer
      日本リンパ学会
    • Place of Presentation
      東京大学 伊藤国際学術研究センター(東京都)
    • Year and Date
      2016-06-24
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2021-01-27  

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