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The development of resolvin-encapsulated negatively-charged liposome for the therapy of acute lung injury

Research Project

Project/Area Number 26861528
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Tabata Yuichi  京都府立医科大学, 医学(系)研究科(研究院), 助教 (70515238)

Research Collaborator Sawa Teiji  京都府立医科大学, 医学研究科, 教授 (10206013)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords炎症消退脂質 / レゾルビン / リポソーム / 炎症 / 肺炎 / 急性呼吸窮迫症候群 / リボソーム内包化レゾルビン
Outline of Final Research Achievements

Recent findings indicate that the resolution of inflammation tends toward being an active process that enables inflamed tissues to return to a state of homeostasis. This process is facilitated by pro-resolving lipid mediators, which are mainly derived from ω6-polyunsaturated fatty acids (PUFA). The bioactive pro-resolving lipid molecules are lipotoxins, resolvins, and protectins. The resolution of inflammation requires pro-resolving mediator-activated programs that stop neutrophil infiltration to inflamed tissues, promote the uptake and clearance of apoptotic inflammatory cells, and stimulate the antimicrobial activities of mucosal epithelial cells. In this study, we developed resolvin-encapsulated negatively-charged liposomes and evaluated the anti-inflammatory effects in in-vitro and in-vivo models. The preliminary findings suggest new possibilities in the development of novel approaches and pharmaceutical therapeutics for the treatment of inflammatory diseases in critical care.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2018 2017

All Presentation (3 results)

  • [Presentation] 小児心臓手術後横隔神経麻痺診断における経肝臓横隔膜超音波検査の有用性:前向き観察研究 第1報2018

    • Author(s)
      田畑雄一,橋本悟,山崎正記,井上美帆
    • Organizer
      第45回日本集中治療医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 小児心臓手術後人工呼吸中における術後横隔神経麻痺エコー診断:後方視的検討2017

    • Author(s)
      田畑雄一、橋本悟、山崎正記、井上美帆
    • Organizer
      第44回日本集中治療医学会
    • Place of Presentation
      札幌
    • Year and Date
      2017-03-09
    • Related Report
      2016 Research-status Report
  • [Presentation] 小児心臓手術後人工呼吸中における術後横隔神経麻痺エコー診断:後方視的検討2017

    • Author(s)
      田畑 雄一,山岸正明,宮崎隆子,前田吉宣,谷口智史,浅田聡,本宮久之,藤田周平
    • Organizer
      第53回日本小児循環器学会総会・学術集会
    • Related Report
      2017 Annual Research Report

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Published: 2014-04-04   Modified: 2019-03-29  

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