| Project/Area Number |
26861534
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | サイトカイン / IL-18 / SERCA2a / Phospholamban / PP2A / Akt / 敗血症性心筋症 / AKT / IL18 / カルシウムハンドリング |
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| Outline of Final Research Achievements |
IL-18 was associated with cardiac dysfunction during sepsis and its ablation exhibited attenuation of septic cardiac dysfunction. We also observed that IL-18 ablation inhibited a decrease of SERCA2a expression and PLN and Akt phosphorylation in septic cardiac dysfunction, which may be regulated by PP2A activation. In cardiac myocytes treated with IL-18, we found a decrease of SERCA2a expression, PLN and Akt phosphorylation, and an increased of PP2A activation. Thus, IL-18 plays important roles in advancing septic cardiac dysfunction by regulating SERCA2a/PLN interaction and Akt through the PP2A.
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