| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Although regulatory T cells (Treg) is one of the major part of the immune suppression, the role of Treg in myocardial infarction(MI) are largely unknown. The aim of this study was to investigate whether inhibiting the excessive immune response enable to suppress myocardial damage in MI. First, we assessed the MI size and remodeling after MI, however, there was no significant differences between Treg-deficient mice and Wild type group . In contrast, Interleukin (IL)-22, a member of the IL-10 cytokine family, plays important role of immune response same as Treg. Now, we found IL-22 administration may reduce the MI size in mice study. The role of IL-22 in MI should be further studied.
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