The role of oral dendritic cells and macrophages in sublingual tolerance induction
| Project/Area Number |
26861542
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
Tanaka Yukinori 東北大学, 歯学研究科(研究院), 特別研究員 (PD) (60637958)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 舌下免疫療法 |
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| Outline of Final Research Achievements |
Sublingual immunotherapy offers a hope of cure for allergies, although the underlying immunological mechanisms, particularly induction of regulatory T (Treg) cells, are still unclear. This study showed that oral dendritic cells (DCs) transported sublingual antigen to draining submandibular lymph nodes and induced antigen-specific Treg cells there. These results identified a previously unappreciated role of oral DCs in Treg cell induction. Targeting oral DCs may enhance the therapeutic effects of sublingual immunotherapy.
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Report
(3 results)
Research Products
(7 results)
