The role of oral dendritic cells and macrophages in sublingual tolerance induction

• Project/Area Number: 26861542
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Morphological basic dentistry
• Research Institution: Tohoku University
• Principal Investigator: Tanaka Yukinori 東北大学, 歯学研究科(研究院), 特別研究員 (PD) (60637958)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 舌下免疫療法

Outline of Final Research Achievements

Sublingual immunotherapy offers a hope of cure for allergies, although the underlying immunological mechanisms, particularly induction of regulatory T (Treg) cells, are still unclear. This study showed that oral dendritic cells (DCs) transported sublingual antigen to draining submandibular lymph nodes and induced antigen-specific Treg cells there. These results identified a previously unappreciated role of oral DCs in Treg cell induction. Targeting oral DCs may enhance the therapeutic effects of sublingual immunotherapy.

Research Products

• [Journal Article] Transportation of sublingual antigens across sublingual ductal epithelial cells to the ductal antigen-presenting cells in mice. (2015)
  • Author(s): Nagai Y, Shiraishi D, Tanaka Y, Nagasawa Y, Ohwada S, Shimauchi H, Aso H, Endo Y, Sugawara S.
  • Journal Title: Clinical and Experimental Allergy Volume: 45 Issue: 3 Pages: 677-686
  • DOI: 10.1111/cea.12329
  • Peer Reviewed / Open Access
• [Journal Article] Resin monomers act as adjuvants in Ni-induced allergic dermatitis in vivo. (2014)
  • Author(s): Bando K, Takahashi H, Kinbara M, Tanaka Y, Kuroishi T, Sasaki K, Takano-Yamamoto T, Sugawara S, Endo Y.
  • Journal Title: journal of dental research Volume: 93 Issue: 11 Pages: 1101-1107
  • DOI: 10.1177/0022034514552674
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Oral classical dendritic cells induce sublingual antigen-specific regulatory T cells in draining lymph nodes (2015)
  • Author(s): Tanaka Y, Nagashima H, Ishii N, Sugawara S
  • Organizer: 第44回日本免疫学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2015-11-18
• [Presentation] 制御性T細胞を誘導する口腔樹状細胞の同定 (2015)
  • Author(s): 田中志典、福本敏、菅原俊二
  • Organizer: 第57回歯科基礎医学会学術大会
  • Place of Presentation: 新潟
  • Year and Date: 2015-09-11
• [Presentation] Oral dendritic cells present sublingual antigen and induce regulatory T cells in the draining lymph nodes (2015)
  • Author(s): Tanaka Y, Nagashima H, Lu L, Ozaki A, Morita Y, Fukumoto S, Ishii N, Sugawara S
  • Organizer: International Congress of Mucosal Immunology (ICMI)
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2015-07-15
  • Int'l Joint Research
• [Remarks] 東北大学大学院歯学研究科口腔生物学講座口腔分子制御学分野ウェブサイト
  • URL: http://www.oral-immunology.dent.tohoku.ac.jp/
• [Remarks] 東北大学大学院歯学研究科口腔生物学講座口腔分子制御学分野 website
  • URL: http://www.oral-immunology.dent.tohoku.ac.jp/index.html