Effects of micronutritional conditions on the expressions of taste receptors and related downstream elements in taste cells
| Project/Area Number |
26861563
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Asahi University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 味覚 / ビタミンＣ / 欠乏 / 味細胞 / 茸状乳頭 / 鼓索神経 / 微量栄養素 / 末梢味覚器 / 味蕾 / ビタミンC / ラット / 受容体 / 酸味 / 塩味 / 嗜好性 |
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| Outline of Final Research Achievements |
The purpose of this study was to examine the effects of vitamin C (VC) deficiency on peripheral taste organ.The results were as follows: The magnitudes of taste nerve responses to some organic acids and high concentrations (>100mM) of NaCl (high Na) in vitamin C deficient (VC-def) rats were smaller than those in non-deficient (ND) rats. Gene expression level of Gad1 and Car4, markers for acid and/or high Na responsive taste cells, decreased in VC-def rats. There was no difference in the number of taste buds on the anterior part of tongue between VC-def and ND rats. The behavioral experiments show that the rejection of citric acid during VC deficiency was decreased. The sodium-dependent VC transporter gene was detected in taste cells of these rats.
The behavioral and neural changes shown in this study may be due to down-expression of gene in high Na and sour responsive taste cells. This study also provide important new information about the presence of VC transport system in taste bud.
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Report
(5 results)
Research Products
(9 results)
