Analysis of Wnt signal network in the differentiation of dental pulp stem cells and clinical dental pulp regeneration by Wnt-signal modified dental pulp stem cells
Project/Area Number |
26861589
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Conservative dentistry
|
Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
Koizumi Yu 東京医科歯科大学, 歯学部, 非常勤講師 (70635549)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 歯髄幹細胞 / Wnt / シグナルネットワーク / 分化誘導 / 歯髄再生 / BMP2 / Wnt5a / Wnt11 / βカテニン / 歯髄細胞 / 象牙芽細胞 / 分化 / 硬組織形成 / Fgf / 歯髄 |
Outline of Final Research Achievements |
Wnt signaling is involved in virtually every aspect of embryonic development, and it is also involved in tooth development including dental pulp tissue. In this project, a crosstalk between Wnt signaling and BMP signaling in the dental pulp stem cells (DPCSs). BMP signaling induces odontoblastic differentiation of DPSCs, and it also stimulates Wnt expression and promotes Wnt signaling. Crosstalk between BMP and Wnt signaling may be essential for odontoblastic differentiation from DPSCs, and effective induction of crosstalk between BMP and Wnt signaling in DPSCs may be a key to promote odontoblastic differentiation in clinical pulp regeneration by DPCSs application.
|
Report
(4 results)
Research Products
(5 results)
-
-
-
-
[Presentation] ALPase Activity of Pulp Cells on EDTA and NaClO-treated Dentin2015
Author(s)
K. Hashimoto, N. Kawashima, A. Y. Bakhit, M. Yamamoto, Y. Koizumi, S. Takahashi, C. Ohi, N. Suzuki
Organizer
IADR/AADR/CADR General Session
Place of Presentation
Hynes Convention Center, Boston, MA, USA
Year and Date
2015-03-11 – 2015-03-14
Related Report
-
[Presentation] Mineralizing Properties of Gingiva-derived Mesenchymal Stem Cells Cultured in 3D-condition2015
Author(s)
N. Kawashima, K. Hashimoto, A. Y. Bakhit, M. Yamamoto, Y. Koizumi, S. Takahashi, C. Ohi, N. Suzuki
Organizer
IADR/AADR/CADR General Session
Place of Presentation
Hynes Convention Center, Boston, MA, USA
Year and Date
2015-03-11 – 2015-03-14
Related Report