Elucidation of the effect of probiotics on caries

• Project/Area Number: 26861615
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Conservative dentistry
• Research Institution: Fukuoka Dental College
• Principal Investigator: FUJIMOTO Akie 福岡歯科大学, 口腔歯学部, 助教 (60707983)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: プロバイオティクス / う蝕菌原因菌 / 齲蝕病原細菌 / う蝕原因菌

Outline of Final Research Achievements

Lactobacillus salivarius WB21 (WB 21) has been reported to improve periodontal disease and halitosis. In this study, the effect of WB 21 on the caries-causing microorganism Streptococcus mutans (Sm) was investigated to further confirm the effect of the oral use of lactic acid bacteria.In mixed culture experiments, it was found that WB21 suppressed Sm growth. In addition, it was found that the addition of WB21 reduced the amount of insoluble glucan produced by Sm.
The results of the present study suggested that WB21 did not increase the risk of dental caries and that it may even have a caries suppression effect.

Research Products

• [Journal Article] Resting salivary flow independently associated with oral malodor (2016)
  • Author(s): Nao Suzuki; Akie Fujimoto; Masahiro Yoneda; Takeshi Watanabe; Takao Hirofuji; Takashi Hanioka.
  • Journal Title: BMC Oral Health Volume: - Issue: 1 Pages: 23-23
  • DOI: 10.1186/s12903-016-0255-3
  • Peer Reviewed / Open Access
• [Journal Article] Inhibitory effect of Enterococcus faecium WB2000 on volatile sulfur compound production by Porphyromonas gingivalis. (2016)
  • Author(s): Nao Suzuki, Takuya Higuchi, Masato Nakajima, Akie Fujimoto, Hiromitsu Morita, Masahiro Yoneda, Takashi Hanioka and Takao Hirofuji.
  • Journal Title: Int J Dent. Volume: -
  • Peer Reviewed / Open Access
• [Journal Article] A cace of oral malodor : Improving the motivation of patients by use of bacterial examination. (2016)
  • Author(s): Yoneda M, Suzuki N, Fujimoto A, Ishii A, Yamada K, Masuo Y, Iwamoto T, Haraga M, Koga C, Morita H, Inoue Y, and Hirofuji T
  • Journal Title: J Oral Hyg Health Volume: - Issue: 2 Pages: 2-2
  • DOI: 10.4172/2332-0702.1000203
  • Peer Reviewed / Open Access
• [Journal Article] Halitosis Patients at a Newly Established Satellite Dental Hospital: Analysis of Patients and the Role of Dental Hygienists (2015)
  • Author(s): Masahiro Yoneda, Miwa Yamada, Nao Suzuki, Rie Uemura, Akie Fujimoto,Hirofumi Fukuchi, Hiromitsu Morita, Kazuhiko Yamada,Tadayuki Matsuo, Ayako Ishii, Chihiro Koga, Takao Hirofuji
  • Journal Title: International Journal of Clinical Preventive Dentistry Volume: 11(1) Pages: 7-14
  • Peer Reviewed / Open Access
• [Journal Article] Acceptance to receive dental treatment performed by students - Comparison of two dental hospitals of Fukuoka Dental College - (2015)
  • Author(s): Masahiro Yoneda, Nao Suzuki, Akie Fujimoto, Yosuke Masuo, Kazuhiko Yamada, Hiromitsu Morita, Chihiro Koga, Takao Hirofuji
  • Journal Title: International Journal of Clinical Preventive Dentistry Volume: 11(2) Pages: 67-71
  • Peer Reviewed / Open Access
• [Journal Article] Lactobacillus salivasius WB21-contianing tablets for the treatment of oral malodor: a double-blind, randomized, placebo-controlled crossover trial-reply to letter. (2015)
  • Author(s): Suzuki N, Yoneda M, Tanabe K, Fujimoto A, Iha K, Seno K, Yamada K, Iwamoto T, Masuo Y, Hrofuji T
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 118 Issue: 4 Pages: 506-506
  • DOI: 10.1016/j.oooo.2014.06.014
  • Peer Reviewed
• [Journal Article] Lactobacillus salivarius WB21-containing tablets for the treatment of oral malodor: a double-blind, randomized, placebo-controlled crossover trial. (2014)
  • Author(s): Suzuki N, Yoneda M, Tanabe K, Fujimoto A, Iha K, Seno K, Yamada K, Iwamoto T, Masuo Y, Hirofuji T
  • Journal Title: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology Volume: 117 Issue: 4 Pages: 462-470
  • DOI: 10.1016/j.oooo.2013.12.400
  • Peer Reviewed / Open Access
• [Journal Article] Effects of S-PRG eluate on oral biofilm and oral malodor. (2014)
  • Author(s): Suzuki N, Yoneda M, Haruna K, Masuo Y, Nishihara T, Nakanishi K, Yamada K, Fujimoto A, Hirofuji T.
  • Journal Title: Archives of Oral Biology Volume: 59 Issue: 4 Pages: 407-413
  • DOI: 10.1016/j.archoralbio.2014.01.009
  • Peer Reviewed / Open Access
• [Journal Article] 新規開設された福岡歯科大学口腔医療センターについて -概要および初診患者分析- (2014)
  • Author(s): 原賀真理子, 米田雅裕, 菅亜里沙, 横上智, 藤本暁江, 石井綾子, 古賀千尋
  • Journal Title: 日歯医療管理誌 Volume: 49 Pages: 58-63
  • Peer Reviewed
• [Presentation] 急性期病院入院中で低栄養状態の有病・高齢患者における口腔カンジダ症に関する検討 (2017)
  • Author(s): 中島正人 森田浩光 山口真広 藤本暁江 脇勇士郎 多々隈寛美 石橋一紘 瀧井慶 桝尾陽介 米田雅裕 廣藤卓雄
  • Organizer: 第26回日本有病者歯科医療学会総会・学術大会
  • Place of Presentation: 石川県 金沢市
  • Year and Date: 2017-03-04
• [Presentation] 洗口剤の薬効成分が口臭におよぼす影響について (2016)
  • Author(s): 永原加那絵 米田雅裕 谷口奈央 藤本暁江 廣藤卓雄
  • Organizer: 9回日本総合歯科学会・学術大会
  • Place of Presentation: 岡山県 岡山市
  • Year and Date: 2016-11-19
• [Presentation] 口臭における唾液分泌量と口腔粘膜水分量の関連性について (2016)
  • Author(s): 藤本暁江 谷口奈央 米田雅裕 森田浩光 渡辺猛 埴岡隆 廣藤卓雄
  • Organizer: 第23回日本歯科医学会総会
  • Place of Presentation: 福岡県 福岡市
  • Year and Date: 2016-10-21
• [Presentation] 口臭の乾燥状態が口臭におよぼす影響について (2016)
  • Author(s): 藤本暁江 谷口奈央 米田雅裕 森田浩光 埴岡隆 廣藤卓雄
  • Organizer: 日本口臭学会第7回学術大会
  • Place of Presentation: 愛知県 名古屋市
  • Year and Date: 2016-06-18
• [Presentation] 喫煙が舌苔の細菌叢に与える影響 (2016)
  • Author(s): 谷口奈央 中野善夫 米田雅裕 森田浩光 桑田文幸 廣藤卓雄 埴岡隆
  • Organizer: 日本口臭学会第7回学術大会
  • Place of Presentation: 愛知県 名古屋市
  • Year and Date: 2016-06-18
• [Presentation] 唾液分泌量と口腔粘膜水分量が口臭に与える影響 (2015)
  • Author(s): 藤本暁江 谷口奈央 米田雅裕
  • Organizer: 日本口臭学会第6回学術大会
  • Place of Presentation: 新潟県新潟市
  • Year and Date: 2015-07-04
• [Presentation] S-PRGイオン溶出液が口腔内細菌バイオフィルムにおよぼす影響 (2015)
  • Author(s): 藤本暁江 米田雅裕 桝尾陽介 山田和彦 森田浩光 廣藤
  • Organizer: 第143回日本歯科保存学会春季学術大会
  • Place of Presentation: 福岡県北九州市
  • Year and Date: 2015-06-25
• [Presentation] Antibiofilm activity of surface pre-reacted glass ionomer (S-PRG)filler. (2015)
  • Author(s): Fujimoto A,Yoneda M,Suzuki N,Masuo Y, Morita H, Oie T, Koga C, Hirofuji T
  • Organizer: 93rd General Session Exhibition of the IADR
  • Place of Presentation: Boston
  • Year and Date: 2015-03-11 – 2015-03-14
• [Presentation] 大学生の喫煙とライフスタイル・ストレスとの関連性 (2014)
  • Author(s): 桝尾陽介、谷口奈央、福地浩文、藤本暁江、伊波幸作、萩尾佳那子、米田雅裕、廣藤卓雄
  • Organizer: 第41回福岡歯科大学学会総会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-12-14
• [Presentation] 歯学部6年生の喫煙実態と生活習慣・ストレスとの関連 (2014)
  • Author(s): 桝尾陽介、谷口奈央、福地浩文、藤本暁江、伊波幸作、萩尾佳那子、米田雅裕、廣藤卓雄
  • Organizer: 第7回日本総合歯科学会総会・学術大会
  • Place of Presentation: 大阪府吹田市
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] 口臭患者の分析および歯科衛生士の役割についての検討 (2014)
  • Author(s): 山田美和, 米田雅裕, 鈴木奈央, 藤本暁江, 森田浩光, 山田和彦, 桝尾陽介, 廣藤卓雄
  • Organizer: 第7回日本総合歯科学会総会・学術大会
  • Place of Presentation: 大阪府吹田市
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] ヒノキチオールのＰｏｒｐｈｙｒｏｍｏｎａｓ ｇｉｎｇｉｖａｌｉｓ に対する抗菌作用と口臭改善効果について (2014)
  • Author(s): 藤本暁江, 谷口奈央, 伊波幸作, 米田雅裕, 山田和彦, 瀬野恵衣, 廣藤卓雄
  • Organizer: 第55回日本歯科医療管理学会
  • Place of Presentation: 札幌市
  • Year and Date: 2014-07-18 – 2014-07-20
• [Remarks] 福岡歯科大学・福岡医療短期大学 研究業績データベース
  • URL: http://www.fdcnet.ac.jp/research/gyouseki/