Carbon nanomateral immobilized peptide for alveolar bone tissue engnieering
| Project/Area Number |
26861616
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Hokkaido University |
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Principal Investigator |
Hirata Eri 北海道大学, 歯学研究科, 助教 (10722019)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | カーボンナノ物質 / ナノテクノロジー / 骨再生 / カーボンナノホーン / ペプチド / 国際共同研究 / 国際研究者交流（フランス） |
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| Outline of Final Research Achievements |
1. The effect of carbon nanohorns on human monocyte and mesenchymal stem cells: CNHs thus accelerating the differentiation of mesenchymal stem cells into the osteoblasts via OSM. This study demonstrates one of the possible mechanisms for bone formation with CNHs and CNHs could be applied for bone regeneration. 2. CNH coated anodized titanium by electrodeposition: CNHs were fixed uniformly by electrophoretic deposition at a voltage 300V, processing time of 180 seconds. 7days after implantation showed new bone tissue contacted with CNHs directly. 3. Development of the CNHs functionalized bone morphogenic protein recepter binded peptide (DWIVA): Osteopontin of the cells cultured with CNH-bone DWIVA was significantly higher than that of CNH-control peptide and DWIVA itself. DWIVA binded CNHs could increase osteoblast differentiation more than DWIVA itself.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Few-Layer Graphene Kills Selectively Tumor Cells from Myelomonocytic Leukemia Patients2017
Author(s)
Julie Russier, Veronica Leon, Marco Orecchioni, Eri Hirata, Patrizia Virdis, Claudio Fozza, Francesco Sgarrella, Gianaurelio Cuniberti, Maurizio Prato, Esterezquez, Alberto Bianco, Lucia G. Delogu
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Journal Title
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume: 56
Issue: 11
Pages: 3014-3019
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Carbon nanohorns allow acceleration of osteoblast differentiation via macrophages activation2016
Author(s)
E. Hirata, E. Miyako, N. Hanagata, N. Ushijima, N. Sakaguchi, J. Russier, M. Yudasaka, S. Iijima, A. Bianco, A. Yokoyama
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Journal Title
Nanoscale,
Volume: 8
Issue: 30
Pages: 14514-14522
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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