Biologic elucidation of memory deficits by tooth loss

Research Project

Project/Area Number	26861641
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Prosthodontics/ Dental materials science and
Research Institution	Hiroshima University
Principal Investigator	Oue Hiroshi 広島大学, 医歯薬保健学研究院(歯), 助教 (70711307)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	歯の喪失 / 脳由来神経栄養因子
Outline of Final Research Achievements	Twenty eight-weeks-old C57BL/6J mice were divided into molar extracted group and molar intact group. We fed the mice either solid or powder. To analyze the memory ability, the step-through passive avoidance test was conducted. BDNF-related mRNA in the hippocampus was analyzed by real-time polymerase chain reaction (RT-PCR). Molar loss group showed memory impairment, and the effect of molar loss on mRNA level were observed. The effect of powder diet on memory ability and mRNA level were not observed. These results suggested that the maintenance of teeth and mastication might be important for prevention of cognitive impairment.

Report

(3 results)