Deveropment of novel bone grafting method focusing on carbonate apatite and statin

• Project/Area Number: 26861643
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Kyushu University
• Principal Investigator: Rakhmatia Yunia Dwi 九州大学, 大学病院, 研究員 (30710214)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 骨補填材料

Outline of Final Research Achievements

We often enconter the situation that there is not enough amount of jaw bone in the dental practice. So, bone grafting technique is one of the importaant options for dental implant treatment. For the bone grafting, bone grafting substitute is one of the most important factors effecting the outcome. But so far, there is no artifitial material superior to autograft. In this study,we focused on the carbonate apatite and statin. We found that carbonate apatite-statin comoposite showed more enhansing effect on new bone formation compared to the conventional hydoroxy apatite.

Research Products

• [Journal Article] Acceleration of hard and soft tissue healing in the oral cavity by a single transmucosal injection of fluvastatin-impregnated poly (lactic-co-glycolic acid) microspheres. An in vitro and rodent in vivo study (2015)
  • Author(s): Yasunami N, Ayukawa Y, Furuhashi A, Atsuta I, Rakhmatia YD, Moriyama Y, Masuzaki T, Koyano K
  • Journal Title: Biomed Mater Volume: 11 Issue: 1 Pages: 015011-015011
  • DOI: 10.1088/1748-6041/11/1/015001
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fibroblast attachment onto novel titanium mesh membranes for guided bone regeneration (2014)
  • Author(s): Rakhmatia YD, Ayukawa Y, Atsuta I, Furuhashi A, Koyano K
  • Journal Title: Odontology Volume: - Issue: 2 Pages: 2180226-2180226
  • DOI: 10.1007/s10266-014-0151-8
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Microcomputed Tomographic and Histomorphometric Analyses of Novel Titanium Mesh Membranes for Guided Bone Regeneration: A Study in Rat Calvarial Defects (2014)
  • Author(s): Yunia Dwi Rakhmatia, Yasunori Ayukawa, Akihiro Furuhashi, Kiyoshi Koyano
  • Journal Title: The International Journal of Oral and Maxillofacial Implants Volume: 29 Pages: 826-835
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Accelerated healing of extraction socket and peri-implant tissue by statin (2015)
  • Author(s): Noriyuku Yasunami, Yasunori Ayukawa, Akihiro Furuhashi, Ikiru Atsuta, Rakhmatia Yunia Dwi, Yasuko Moriyama, Kiyoshi Koyano
  • Organizer: International Association for Dental Research
  • Place of Presentation: アメリカ、ボストン
  • Year and Date: 2015-03-11 – 2015-03-13
• [Presentation] Effectiveness of novel micro-porous titanium mesh membrane for guided bone regeneration in early stage healing of canine mandible defect (2014)
  • Author(s): Yunia Dwi Rakhmatia, Yasunori Ayukawa, Yohei Jinno, Akihiro Furuhashi, Kiyoshi Koyano
  • Organizer: Indonesia Prosthodontic Society and Japan Prosthodontic Society Joint Meeting
  • Place of Presentation: インドネシア、バリ島
  • Year and Date: 2014-10-31 – 2014-11-01