A new strategy for patients with xerostomia targeting ion channels by hyperthermia

Research Project

Project/Area Number	26861648
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Prosthodontics/ Dental materials science and
Research Institution	Kyushu Dental College
Principal Investigator	Taro Mukaibo 九州歯科大学, 歯学部, 助教 (50635117)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	TRPチャネル / 口腔乾燥症 / SOCE / 唾液分泌 / ハイパーサーミア / Ex vivo顎下腺灌流
Outline of Final Research Achievements	The aim of this study was to elucidate the mechanism of increased saliva secretion of salivary gland associated with temperature. Although TPR channel was studied as a SOCE (Store Operated Calcium Channel), that possibility was little according to the results of this study. Moreover, any difference was not detected in localization of channels and transporters relevant to saliva secretion between 25℃ and 37℃．Further study is necessary to show the mechanism of increased saliva secretion in accordance with the elevated temperature.