Expression pattern and functional analysis of Hox genes in the tooth germ development
| Project/Area Number |
26861676
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 歯胚発生 / Hox遺伝子群 |
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| Outline of Final Research Achievements |
As for the mechanism of tooth development, the total picture does not yet become clear. A purpose of this study is to elucidate a relation to the dental germ outbreak of the Hox gene. 13 Hox genes emerge in the mandibular first molar dental germ of the mouse of the age on viviparous 13,14,18 day. We paid attention to Hoxd12 that connection with Shh which was a key regulator to development of tooth is doubted. With a rat odontogenic epithelium cell, I examined an association between Hoxd12 gene and Ambn and Shh which was an ameloblast differentiation marker. When Hoxd12 gene emerges, the expression of both genes changes. The possibility that expression of Hoxd12 was related to expression of Shh, Ambn was suggested.
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Report
(3 results)
Research Products
(1 results)
