| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Historically, several autologous platelet concentrates (APCs) have been used to promote healing. Platelet-rich fibrin (PRF) have been reported to be effective in the acceleration of tissue healing and bone regeneration following oral surgery procedures.The aim of the present study was to evaluate the effectiveness of PRF as an accelerator of wound healing in patients undergoing oral BP therapy and requiring tooth extractions. The study also aimed to explore the possibility of its use as a method of prophylaxis for MRONJ.
As a result,early epithelization was confirmed in all PRF patients including patients receiving steroids and immunosuppressants. Thus, PRF may reduce the risk of delayed recovery in tooth extracted patients undergoing oral bisphosphonate therapy. Moreover, PRF may be useful in preventing medication-related osteonecrosis of the jaw (MRONJ) in patients receiving oral BP.
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