Research Project
Grant-in-Aid for Young Scientists (B)
In this study, we have attempted to estimate the capability of metabolomics approach for detection of oral squamous cell carcinoma (OSCC) using saliva from patients. Saliva samples were obtained from 70 OSCC patients and 28 healthy adult volunteers. Capillary electrophoresis-time-of-flight mass spectrometry was employed for comprehensive analysis of metabolites. The area under the curve (AUC) more than 0.50 between OSCC patients and healthy volunteers were observed in 27 metabolites. Butanoate showed the highest AUC (0.6428) and statistically significant difference for the patients with OSCC compared with healthy volunteers. Moreover analysis for multiple metabolites improved diagnostic accuracy more than for a single metabolite. These results suggested that OSCC specific salivary metabolic profiles may be a useful diagnostic tool for the patients with OSCC.
All 2015 2014
All Journal Article (1 results) (of which Peer Reviewed: 1 results, Open Access: 1 results) Presentation (5 results)
Int J Oncol.
Volume: 46 Issue: 5 Pages: 1971-1977
10.3892/ijo.2015.2912
