• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of epigenomic alterations in chemoresistance and radioresistance of oral squamous cell carcinoma to provide the personalized medicine.

Research Project

Project/Area Number 26861738
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionKumamoto University

Principal Investigator

Hirosue Akiyuki  熊本大学, 医学部附属病院, 助教 (00638182)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords口腔癌 / エピゲノム / DNAメチル化 / ヒストン修飾 / 抗癌剤耐性 / 放射線耐性 / エピジェネティクス治療薬
Outline of Final Research Achievements

Chemo-radiotherapy resistance is a key obstacle to effective cancer treatment in oral squamous cell carcinoma (OSCC). Epigenomic alterations, particularly DNA methylation have been extensively studied for future diagnosis, prognosis and prediction of therapeutic response in a variety of cancers. However, the contribution of epigenetic changes to the development of chemo-radiotherapy resistance in OSCC remains to be elucidated. Herein, we investigated the relevance between clinical effect and epigenomic alterations in OSCC to develop the novel diagnostic methods based on epigenomic profile. DNA methylation frequencies were evaluated by quantitative methylation specific PCR (MSP) assay. MSP assay indicated that hypermethylation of MGMT, TFAP2E and DAPK1 was associated with pathological response to 5-FU based chemo-radiotherapy and overall survival. These results suggest that methylation status of these genes may provide the prediction of chemosensitivity and radiosensitivity in OSCC.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2016 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Pre-treatment neutrophil to lymphocyte ratio predicts the chemoradiotherapy outcome and survival in patients with oral squamous cell carcinoma2016

    • Author(s)
      Hikaru Nakashima, Yuichiro Matsuoka, Ryoji Yoshida, Masashi Nagata, Akiyuki Hirosue, Kenta Kawahara, Jyunki Sakata, Hidetaka Arita, Akimitsu Hiraki and Hideki Nakayama
    • Journal Title

      BMC Cancer

      Volume: 26 Issue: 1 Pages: 41-41

    • DOI

      10.1186/s12885-016-2079-6

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The tumour stromal features are associated with resistance to 5-FU-based chemoradiotherapy and a poor prognosis in patients with oral squamous cell carcinoma.2015

    • Author(s)
      Matsuoka Y, Yoshida R, Nakayama H, Nagata M, Hirosue A, Tanaka T, Kawahara K, Nakagawa Y, Sakata J, Arita H, Hiraki A, Shinohara M.
    • Journal Title

      APMIS

      Volume: 3 Issue: 3 Pages: 205-14

    • DOI

      10.1111/apm.12344

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phase II clinical trial of multiple peptide vaccination for advanced head and neck cancer patients revealed induction of immune responses and improved OS2015

    • Author(s)
      Yoshitake, Y., Fukuma, D., Yuno, A., Hirayama, M., Nakayama, H., Tanaka. T., Nagata, M., Takamune, Y., Kawahara, K., Nakagawa, Y., Yoshida, R., Hirosue, A., Ogi, H., Hiraki, A. , Jono, H., Hamada, A., Yoshida, K., Nishimura, Y., Nakamura, Y., Shinohara, M.
    • Journal Title

      Clinical Cancer Research

      Volume: 21 Issue: 2 Pages: 312-321

    • DOI

      10.1158/1078-0432.ccr-14-0202

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A case of adenomatoid odontogenic tumor-like tumor, unusual benign odontogenic tumor in the maxilla.2015

    • Author(s)
      Kawahara K., Nakayama H., Fukuma D., Nagata M., Yoshida R., Tanaka T., Nakagawa Y., Hirosue A., Hiraki A., Takeda Y & Shinohara M.
    • Journal Title

      Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

      Volume: 27 Issue: 2 Pages: 299-302

    • DOI

      10.1016/j.ajoms.2014.05.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] Epigenetic alterations in chemoresistance and radioresistance of oral squamous cell carcinoma.2015

    • Author(s)
      A. Hirosue, M. Nakamoto, T. Yamamoto, Y. Matsuoka, C. Nakamura, K. Kawahara, R. Yoshida, A. Hiraki, H. Nakayama, M. Shinohara
    • Organizer
      22nd International conference on oral & maxillofacial surgery
    • Place of Presentation
      メルボルン、オーストラリア
    • Year and Date
      2015-10-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Increased expression of HMGA2 predicts metastasis and poor prognosis in oral squamous cell carcinoma.2015

    • Author(s)
      Junki S,Akiyuki H,Ryoji Y,Masashi N,Yuichiro M,Hidetaka A,Kenta K,Yoshihiro N. Masashi N,Akimitsu H,Masanori S,Hideki N
    • Organizer
      第74回日本癌学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Epigenetic alterations in the drug resistance of oral squamous cell carcinoma.2014

    • Author(s)
      Akiyuki Hirosue
    • Organizer
      96th Annual Meeting, Scientific Sessions & Exhibition in conjunction with the Japanese Society and Korean Association of Oral and Maxilllofacial Surgeons
    • Place of Presentation
      Hawaii Convention Center
    • Year and Date
      2014-09-08 – 2014-09-13
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi