Novel strategy for molecular diagnosis and treatment in oral cancer by MIA gene family signaling pathway.
| Project/Area Number |
26861742
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Nara Medical University |
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Principal Investigator |
Kurihara Miyako 奈良県立医科大学, 医学部附属病院, 診療助教 (40453170)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 口腔癌 / MIA gene family / 浸潤・転移 |
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| Outline of Final Research Achievements |
In this study, we determined that MIA facilitates STOX2 expression.In vitro analysis using OSCC cells revealed that MIA siRNA decreased expression of STOX2. Moreover, STOX2 accelerated OSCC cell growth, invasion, suppressed apoptosis, and enhanced resistance to paclitaxel, cisplatin, and 5-FU.MIA and STOX2 mRNA levels were higher in OSCCs than in normal oral epithelial cells, and upregulation of STOX2 was significantly correlated with overexpression of MIA. In 202 OSCC specimens, immunostaining for STOX2 was associated with nodal metastasis and MIA expression. Furthermore, MIA expression and STOX2 expression were associated with poor outcome in OSCCs. Our results suggest that MIA-STOX2 signaling may be a useful diagnostic and therapeutic target in OSCCs.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] 18F-fluoro-2-deoxyglucose-positron emission tomography for the assessment of histopathological response after preoperative chemoradiotherapy in oral squamous cell carcinoma.2015
Author(s)
Shimomura H, Sasahira T, Yamanaka Y, Kurihara M, Imai Y, Tamaki S, Yamakawa N, Shirone N, Hasegawa M, Kuniyasu H, Kirita T
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Journal Title
International Journal of Clinical Oncology
Volume: 20(2)
Issue: 2
Pages: 308-316
DOI
Related Report
Peer Reviewed / Open Access
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