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The development of novel therapies that target glutamate receptors for oral cancer

Research Project

Project/Area Number 26861750
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionNihon University

Principal Investigator

HONDA Kuniya  日本大学, 歯学部, ポスト・ドクトラル・フェロー (20548945)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords癌性疼痛 / 代謝型グルタミン酸受容体 / 代謝型グルタミン受容体 / 癌細胞の増殖・分化 / グルタミン酸受容体
Outline of Final Research Achievements

It is known that peripheral metabotropic glutamate receptor (mGluR) 1 and 5 are involved in abnormal pain following peripheral nerve injury and inflammation. Moreover, mGluRs express in cancer cell membrane and mGluRs signaling may induce cancer cell proliferation. However, involvement of mGluR5 signaling in cancer pain and cancer growth is not fully clarified. To clarify the mechanisms underlying initiation/maintenance of cancer pain and cancer cell proliferation, we performed behavioral testing and immunohistochemistry. Present findings suggest that peripheral mGluR5 signaling is involved in cancer induced mechanical hypersensitivity and cancer growth in orofacial region.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (11 results)

All 2016 2015 2014

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Open Access: 7 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Connexin 43 contributes to ectopic orofacial pain following inferior alveolar nerve injury.2016

    • Author(s)
      Kaji K, Shinoda M, Honda K, Unno S, Shimizu N, Iwata K.
    • Journal Title

      Mol Pain.

      Volume: 8 Pages: 12-12

    • DOI

      10.1177/1744806916633704

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of transient receptor potential vanilloid 1 expression in trigeminal ganglion neurons via methyl-CpG binding protein 2 signaling contributes tongue heat sensitivity and inflammatory hyperalgesia in mice.2016

    • Author(s)
      Suzuki A, Shinoda M, Honda K, Shirakawa T, Iwata K
    • Journal Title

      Molecular Pain

      Volume: 12 Pages: 1-11

    • DOI

      10.1177/1744806916633206

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Involvement of peripheral artemin signaling in tongue pain: possible mechanism in burning mouth syndrome.2015

    • Author(s)
      Shinoda M, Takeda M, Honda K, Maruno M, Katagiri A, Satoh-Kuriwada S, Shoji N, Tsuchiya M, Iwata K
    • Journal Title

      Pain

      Volume: 156 Issue: 12 Pages: 2528-2537

    • DOI

      10.1097/j.pain.0000000000000322

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] p38 phosphorylation in medullary microglia mediates ectopic orofacial inflammatory pain in rats.2015

    • Author(s)
      Kiyomoto M, Shinoda M, Honda K, Nakaya Y, Dezawa K, Katagiri A, Kamakura S, Inoue T, Iwata K.
    • Journal Title

      Mol Pain.

      Volume: 12 Pages: 48-48

    • DOI

      10.1186/s12990-015-0053-y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Involvement of TRPV1 and TRPA1 in incisional intraoral and extraoral pain.2015

    • Author(s)
      Urata K, Shinoda M, Honda K, Lee J, Maruno M, Ito R, Gionhaku N, Iwata K.
    • Journal Title

      J Dent Res.

      Volume: 94 Issue: 3 Pages: 446-54

    • DOI

      10.1177/0022034514565645

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Morphological and functional changes in regenerated primary afferent fibres following mental and inferior alveolar nerve transection2014

    • Author(s)
      Tsuboi Y, Honda K, Bae YC, Shinoda M, Kondo M, Katagiri A, Echizenya S, Kamakura S, Lee J, Iwata K.
    • Journal Title

      Eur J Pain

      Volume: - Issue: 9 Pages: 1258-1266

    • DOI

      10.1002/ejp.650

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TRPA1 contributes to capsaicin-induced facial cold hyperalgesia in rats.2014

    • Author(s)
      Honda K, Shinoda M, Furukawa A, Kita K, Noma N, Iwata K.
    • Journal Title

      Eur J Oral Sci.

      Volume: 122 Issue: 6 Pages: 391-6

    • DOI

      10.1111/eos.12157

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Metabotropic glutamate receptor signaling is involved in cancer pain and cancer growth2015

    • Author(s)
      Kuniya Honda, Masamichi Shinoda and Koichi Iwata
    • Organizer
      第57回歯科基礎医学会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Metabotropic glutamate receptor signaling is involved in cancer pain and cancer growth2015

    • Author(s)
      Kuniya Honda, Masamichi Shinoda and Koichi Iwata
    • Organizer
      9th Congress of the European Pain Federation EFIC
    • Place of Presentation
      Vienna (Austria)
    • Year and Date
      2015-09-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] TRPA1 contributes to capsaicin-induced facial cold hyperalgesia in rats2015

    • Author(s)
      Kuniya Honda, Masamichi Shinoda and Koichi Iwata
    • Organizer
      4th International Congress on Neuropathic Pain
    • Place of Presentation
      Nice (France)
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Activation of peripheral mGluR5 contributes thermal and mechanical hyperalgesia via TRPA1 and TRPV12014

    • Author(s)
      Kuniya Honda, Masamichi Shinoda, Koichi Iwata
    • Organizer
      第56回歯科基礎医学会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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