The development of novel therapies that target glutamate receptors for oral cancer
| Project/Area Number |
26861750
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
HONDA Kuniya 日本大学, 歯学部, ポスト・ドクトラル・フェロー (20548945)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 癌性疼痛 / 代謝型グルタミン酸受容体 / 代謝型グルタミン受容体 / 癌細胞の増殖・分化 / グルタミン酸受容体 |
|---|
| Outline of Final Research Achievements |
It is known that peripheral metabotropic glutamate receptor (mGluR) 1 and 5 are involved in abnormal pain following peripheral nerve injury and inflammation. Moreover, mGluRs express in cancer cell membrane and mGluRs signaling may induce cancer cell proliferation. However, involvement of mGluR5 signaling in cancer pain and cancer growth is not fully clarified. To clarify the mechanisms underlying initiation/maintenance of cancer pain and cancer cell proliferation, we performed behavioral testing and immunohistochemistry. Present findings suggest that peripheral mGluR5 signaling is involved in cancer induced mechanical hypersensitivity and cancer growth in orofacial region.
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Report
(3 results)
Research Products
(11 results)
