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A study of novel BP180 C-terminal domain ELISA on mucous membrane pemphigoid

Research Project

Project/Area Number 26861762
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionKyushu University

Principal Investigator

Yasukochi Atsushi  九州大学, 歯学研究科(研究院), 研究員 (30724968)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords口腔外科学 / 歯学 / 粘膜類天疱瘡
Outline of Final Research Achievements

Diagnosis of anti-BP180-type mucous membrane pemphigoid (BP180-MMP) is frustrated by the difficulty of detecting BP180 reactivity. 332 patients were tentatively diagnosed with BP180-MMP.
Clinically, a predominance of female patients was diagnosed. Oral mucosal and cutaneous lesions were found in 85.5% and 41.0% of patients, respectively, and frequent treatments were systemic steroids.
Various immunological methods, including a newly developed BP180 C-terminal domain enzyme-linked immunoassay (BP180CT ELISA), revealed frequent reactivity with BP180 C-terminal on MMP patients. This large study of patients with suspected BP180-MMP indicates the difficulty of diagnosis of BP180-MMP and the diagnostic usefulness of BP180 CT ELISA.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014 2013

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Clinical and Immunological Study of 332 Japanese Patients Tentatively Diagnosed with Anti-BP180-type Mucous Membrane Pemphigoid: A Novel BP180 C-terminal Domain Enzyme-linked Immunosorbent Assay.2016

    • Author(s)
      Yasukochi A, Teye K, Ishii N, Hashimoto T.
    • Journal Title

      Acta Derm Venereol.

      Volume: 0 Pages: 0-0

    • DOI

      10.2340/00015555-2407

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Granular C3 Dermatosis.2016

    • Author(s)
      Hashimoto T, Tsuruta D, Yasukochi A, Imanishi H, Sekine H, Fujita T, Wanibuchi H, Gi M, Kárpáti S, Sitaru C, Zone JJ, Endo D, Abe S, Nishino T, Koji T, Ishii N.
    • Journal Title

      Acta Derm Venereol

      Volume: 00 Pages: 00-00

    • DOI

      10.2340/00015555-2379

    • NAID

      120006987674

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Anti-BP180-type oral mucous membrane pemphigoid reactive to both NC16a and C-terminal domains.2015

    • Author(s)
      Uchiyama M, Mitsuhashi Y, Tsuboi R, Ishii N, Hayakawa T, Yasukochi A, Hashimoto T.
    • Journal Title

      Indian J Dermatol Venereol Leprol.

      Volume: 81 Issue: 6 Pages: 637-639

    • DOI

      10.4103/0378-6323.168330

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Case of subepidermal autoimmune bullous disease with psoriasis vulgaris reacting to both BP180 C-terminal domain and laminin gamma-1.2015

    • Author(s)
      Ishida S, Takahashi K, Kanaoka M, Okawa T, Tateishi C, Yasukochi A, Ishii N, Li X, Hashimoto T, Aihara M.
    • Journal Title

      J Dermatol.

      Volume: 42 Issue: 4 Pages: 391-393

    • DOI

      10.1111/1346-8138.12801

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of concurrent anti-laminin γ1 pemphigoid and anti-laminin 332-type mucous membrane pemphigoid2014

    • Author(s)
      Li X, Qian H, Ishii N, Yamaya M, Fukuda H, Mukai H, Hirako Y, and Hashimoto T
    • Journal Title

      Br J Dermatol

      Volume: 171 Issue: 6 Pages: 1555-1557

    • DOI

      10.1111/bjd.13113

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of lichen planus pemphigoides with autoantibodies to the NC16a and C-terminal domains of BP180 and to desmoglein-1.2014

    • Author(s)
      Sekiya A, Kodera M, Yamaoka T, Iwata Y, Usuda T, Ohzono A, Yasukochi A, Koga H, Ishii N, Hashimoto T.
    • Journal Title

      Br J Dermatol.

      Volume: 171 Issue: 5 Pages: 1230-1235

    • DOI

      10.1111/bjd.13097

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immunological and Statistical Studies of Anti-BP180 Antibodies in Paraneoplastic Pemphigus2014

    • Author(s)
      Tsuchisaka A, Kawano H, Yasukochi A, Teye K, Ishii N, Koga H, Sogame R, Ohzono A, Krol RP, Kawakami T, Furumura M, Ohata C, Li X, Hashimoto T
    • Journal Title

      J Invest Dermatol

      Volume: 134 Issue: 8 Pages: 2283-2287

    • DOI

      10.1038/jid.2014.151

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of cathepsin E in decidual macrophage of patients with recurrent miscarriage.2014

    • Author(s)
      Goto S, Ozaki Y, Suzumori N, Yasukochi A, Kawakubo T, Furuno T, Nakanishi M, Yamamoto K, Sugiura-Ogasawara M.
    • Journal Title

      Mol Hum Reprod.

      Volume: 20 Issue: 5 Pages: 454-462

    • DOI

      10.1093/molehr/gau008

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cathepsin E in mammary gland: Repression of cathepsin E expression increases the risk of mammary carcinogenesis and links to poor prognosis in breast cancer.2013

    • Author(s)
      Tomoyo Kawakubo, Atsushi Yasukochi, Tatsuya Toyama, Satoru Takahashi, Kuniaki Okamoto, Takayuki Tsukuba, Seiji Nakamura, Yasuhiko Ozaki, Koichi Nishigaki, Hiroko Yamashita, and Kenji Yamamoto
    • Journal Title

      Carcinogenesis

      Volume: 00 Issue: 3 Pages: 1-13

    • DOI

      10.1093/carcin/bgt373

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] IgA沈着が主体だった抗BP180型口腔粘膜型類天疱瘡の1例2014

    • Author(s)
      井上智子、 矢上晶子、高橋正幸、岩田洋平、石井文人、安河内篤、橋本隆、松永佳世子
    • Organizer
      第113回 日本皮膚科学会総会
    • Place of Presentation
      岡山
    • Year and Date
      2014-05-30 – 2014-06-02
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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