The elucidation of mechanotransduction of integrins and establishment of the PCR prevention with integrins inhibitor

Research Project

Project/Area Number	26861788
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Orthodontics/Pediatric dentistry
Research Institution	Hiroshima University
Principal Investigator	Hirose Naoto 広島大学, 医歯薬保健学研究院, 助教 (50611935)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	インテグリン / ＰＣＲ / 顎関節症 / PCR / 下顎頭吸収
Outline of Final Research Achievements	We ocnducted experiments for searching for the new treatment for PCR. It was already elucidated that mechanical stress was received at integrins on the surface of chondrocytes'cell membrane. We elucidated in this research that Cilengitide, which is the inhibitor of integrinαVβ5, inhibits receptive mechanism and finally suppresses the expression of inflammatory cytokines via integrin-FAK signaling. Additionally, We establish the rat model which condyle becomes overloaded in vivo experiments. however, we weren't able to accomplish this task because of some difficulties of how to inject cilengitide and reach it there.