| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
The purpose of this study was to clarify the osteoblasts differentiation of periodontal ligament fibroblasts in tension zone during orthodontic tooth movement, focusing on methylation modification at histone H3 lysine 9 (H3K9) from the view point of epigenetics control.
We observed the changes that localization of methylated H3K9 modifications with peak at 7th days after tooth movement in periodontal ligament fibroblasts. In addition, it was suggested that the H3K9 methyltransferases acted in the periodontal ligament fibroblasts in the tension zone and the H3K9 methylation modification change was occurred in time-dependent.
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