Study of osteoblasts differentiation of periodontal ligament fibroblasts by epigenetic control in tension zone during orthodontic tooth movement
| Project/Area Number |
26861802
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 歯科矯正治療 / 歯根膜線維芽細胞 / エピジェネティクス / 矯正力 / 骨芽細胞 / 歯の移動 |
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| Outline of Final Research Achievements |
The purpose of this study was to clarify the osteoblasts differentiation of periodontal ligament fibroblasts in tension zone during orthodontic tooth movement, focusing on methylation modification at histone H3 lysine 9 (H3K9) from the view point of epigenetics control.
We observed the changes that localization of methylated H3K9 modifications with peak at 7th days after tooth movement in periodontal ligament fibroblasts. In addition, it was suggested that the H3K9 methyltransferases acted in the periodontal ligament fibroblasts in the tension zone and the H3K9 methylation modification change was occurred in time-dependent.
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Report
(4 results)
Research Products
(6 results)
