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Elucidating the mechanism of drug-indcued gingival overgrowth using disease model

Research Project

Project/Area Number 26861815
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Periodontology
Research InstitutionHiroshima University

Principal Investigator

Matsuda Shinji  広島大学, 大学病院, 病院助教 (30611321)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords薬物性歯肉増殖症 / シクロスポリン / マウスモデル / 動物モデル
Outline of Final Research Achievements

Conventional therapy for drug-induced gingival overgrowth(DIGO) is demanded. Animal disease model is essential for developing novel therapy. In the current study we developed mouse DIGO model by which silk sutures were pre-ligated before the application of CsA. Anitibiotics inhibited the initiation of CsA induced gingival overgrowth. Furtheremore tacrolimus which have calcineurin inhibition activity same as CsA also induced gingival overgrowth. Cessation of CsA administration improved gingival overgrowth. In conclusion, Bacteriao infection and calcineurin activity is involved in initiation of CsA indced gingival overgrowth. In the future, it is promising that revealing the mechanismas of DIGO by using our mouse DIGO model.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (6 results)

  • [Journal Article] Brain-derived neurotrophic factor prevents the endothelial barrier dysfunction induced by interleukin-1β and tumor necrosis factor-α2015

    • Author(s)
      Matsuda S, Fujita T, Kajiya M, Kashiwai K, Takeda K, Shiba H, Kurihara H.
    • Journal Title

      Journal of periodontal research

      Volume: 50(4) Issue: 4 Pages: 444-451

    • DOI

      10.1111/jre.12226

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 疾患モデルマウスを用いた薬物性歯肉増殖症の病態解明2015

    • Author(s)
      岡信 愛、松田真司, 藤田 剛, 加治屋幹人, 内田雄士, 栗原英見
    • Organizer
      第99回広島大学歯学会
    • Place of Presentation
      広島市
    • Year and Date
      2015-11-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of Calcineurin Inhibitor Induced Gingival Hyperplasia Mice Model2015

    • Author(s)
      岡信 愛、松田真司, 加治屋幹人, 水野智仁, 藤田 剛, 栗原英見
    • Organizer
      第6回広島カンファレンス
    • Place of Presentation
      広島市
    • Year and Date
      2015-10-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] カルシニューリン阻害薬誘導性歯肉増殖症の病態解明2015

    • Author(s)
      岡信 愛、松田真司, 加治屋幹人, 内田雄士, 水野智仁, 藤田 剛, 栗原英見
    • Organizer
      第58回秋季日本歯周病学会学術大会
    • Place of Presentation
      浜松市
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] カルシニューリン阻害剤に誘導される歯肉増殖症の病態解明2015

    • Author(s)
      岡信 愛、松田真司, 加治屋幹人, 水野智仁, 藤田 剛, 栗原英見
    • Organizer
      日本歯科保存学会 2015年度春季学術大会(第142回)
    • Place of Presentation
      北九州市
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 薬物性歯肉増殖症のモデルマウスの確立2014

    • Author(s)
      岡信 愛
    • Organizer
      第62回国際歯科研究学会日本部会総会・学術大会
    • Place of Presentation
      大阪 ・ KKRホテル大阪
    • Year and Date
      2014-12-04 – 2014-12-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 疾患モデルマウスを用いた薬物性歯肉増殖症の病態解明2014

    • Author(s)
      岡信 愛
    • Organizer
      第57回秋季日本歯周病学会学術大会
    • Place of Presentation
      神戸 ・ 神戸国際会議場・神戸国際展示場
    • Year and Date
      2014-10-18
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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