Fundamental study on dosage form of acylated homoserine lactone based on technological development of new scalp hair promotion care

• Project/Area Number: 26861851
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Fundamental nursing
• Research Institution: Teikyo University
• Principal Investigator: Nishijima Yoshimi 帝京大学, 医学部, 助教 (10710733)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: スカルプケア / アシル化ホモセリンラクトン / AHL / 発毛促進

Outline of Final Research Achievements

This is a basic study on administrative method of acylated homoserine lactone (AHL), of which hair growth action is already established, for technological development of scalp hair promotion care.
The administrative condition with lotion type was clarified, however external use preparation was not developed. Further studies is necessary for scalp hair promotion care based on investigation of the mechanism of AHL effect on the skin.

Research Products

• [Journal Article] Expression profiles of the antioxidant enzymes gene (SOD1, CAT, GPX, and HMOX1) in the skin of UV-irradiated and obese mice (2016)
  • Author(s): Yoshimi Nishijima, Ai Ibuki, Takeo Minematsu, Hiromi Sanada
  • Journal Title: Journal of nursing science and engineering Volume: 3 Pages: 13-20
  • NAID: 130006406635
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 発毛促進作用を発揮するアシル化ホモセリンラクトンの投与方法の検討 (2014)
  • Author(s): 西島 良美、峰松 健夫、萩原 治夫、真田 弘美
  • Organizer: 第19回日本臨床毛髪学会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2014-11-23 – 2014-11-24
• [Presentation] アシル化ホモセリンラクトンの抗酸化能の検証 (2014)
  • Author(s): 西島 良美、峰松 健夫、田崎 なつみ、Rajendran K Naresh、真田 弘美
  • Organizer: 第23回日本創傷・オストミー・失禁管理学会
  • Place of Presentation: 大宮ソニックシティ
  • Year and Date: 2014-05-16 – 2014-05-17
• [Presentation] The N-(3-oxododwcanoyl)-L-homoserine lactone promotes wound healing through the up regulation of HMOX1 and inhibits oxidative stress in diabetic rats. (2014)
  • Author(s): Naresh Kumar, Takeo Minematsu, Yoshimi Nishijima, Gojiro Nakagami, Hiromi Sanada
  • Organizer: 第23回日本創傷・オストミー・失禁管理学会
  • Place of Presentation: 大宮ソニックシティ
  • Year and Date: 2014-05-16 – 2014-05-17
• [Book] 看護理工学 (真田弘美、森武俊編) Ⅲ 看護学における生物学的アプローチ (2015)
  • Author(s): 真田弘美、村山陵子、峰松健夫、飯坂真司、玉井奈緒、池田真一、西島良美、森武俊、野口博史、藪中幸一、吉田美香子、大江真琴、仲上豪二朗
  • Total Pages: 234
  • Publisher: 東京大学出版会
• [Remarks]
  • URL: http://www.rounenkango.m.u-tokyo.ac.jp/