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Changes in lipid peroxides over time in vernix caseosa in the early neonatal period and their effects on skin barrier function

Research Project

Project/Area Number 26861937
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Lifelong developmental nursing
Research InstitutionOita University of Nursing and Health Sciences

Principal Investigator

HIGUCHI SACHI  大分県立看護科学大学, 看護学部, 助教 (10567209)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords看護学 / 新生児 / 皮膚バリア機能 / 胎脂 / 保清 / ドライテクニック
Outline of Final Research Achievements

Dry techniques have recently been introduced to cleaning care in the early neonatal period. This study aimed to clarify the effects of preserved vernix caseosa on the skin. To achieve this, we measured lipid peroxides in vernix caseosa over time and evaluated skin barrier function and inflammatory reactions in the skin tissue of neonates.
Our results revealed that some neonates exhibit high levels of hexanoyl-lysine, an initial lipid peroxide in vernix caseosa, immediately after birth with subsequent repeated fluctuations (peroxidation chain reaction), while other neonates exhibit low levels immediately after birth with no subsequent fluctuations (no oxidation). Furthermore, our findings suggested that skin cleaning care (during the preservation period of vernix caseosa) can cause changes in the skin barrier function and inflammatory reactions within the skin of neonates.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2015

All Presentation (1 results)

  • [Presentation] 早期新生児期における額部の皮膚バリア機能と炎症性サイトカイン発現との関連2015

    • Author(s)
      樋口幸
    • Organizer
      第3回看護理工学会学術集会
    • Place of Presentation
      京都府
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2019-03-29  

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