| Project/Area Number |
26870026
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
Gastroenterology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
SAWADA Koji 旭川医科大学, 医学部, 助教 (80548660)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | NAFLD / プロバイオティクス / 脂質代謝 / 腸内細菌叢 / Toll-like receptor |
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| Outline of Final Research Achievements |
In this study, we investigated whether a probiotic (Lactobacillus brevis SBC8803) improved non-alcoholic fatty liver disease in NAFLD model mice fed with a high fat diet. In mice fed with the probiotics, increasing body weight was inhibited after 28-33 weeks, however; longer treatment with the probiotic did not induce the inhibition of increasing body weight and histopathological examination did not demonstrate an improvement of fatty liver compared with those of NAFLD mice, because of decreasing body weight in both of NAFLD mice and mice treated with the probiotic. In the future, it will be needed to investigate whether short term treatment with the probiotic improves NAFLD.
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