Hypothalamic-Pituitary-Adrenal Axis and Brain Activity in IBS
| Project/Area Number |
26870039
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
General internal medicine(including psychosomatic medicine)
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| Research Institution | Tohoku University |
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Principal Investigator |
Tanaka Yukari 東北大学, 東北メディカル・メガバンク機構, 助教 (50721453)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 過敏性腸症候群 / 脳腸相関 / 自律神経活動 / 副腎皮質刺激ホルモン放出ホルモン / ストレス / 自律神経 / 神経内分泌 / ストレス関連ホルモン / 心拍変動 / ストレス科学 / 消化器内科学 / 神経科学 / 心身医学 |
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| Outline of Final Research Achievements |
Corticotropin-releasing hormone (CRH) mediates stress responses in the brain-gut axis. Exogenous CRH differentially sensitizes brain regions of the emotional-arousal circuitry within the visceral pain matrix to colorectal distention and synergetic activation of noradrenergic function in IBS patients and healthy individuals. Administration of CRH also modulates the autonomic nervous system in response to colorectal distention. The relationship between HPA-sympathoadrenal responses and CRH levels during colorectal distention differs between patients with IBS and controls. Modulation of adrenal gland activity in response to ACTH stimulation may contribute to the brain-gut pathophysiology characteristic of IBS.
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Report
(5 results)
Research Products
(20 results)
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[Journal Article] Differential activation in amygdala and plasma noradrenaline during colorectal distention by administration of corticotropin-releasing hormone between healthy individuals and patients with irritable bowel syndrome.2016
Author(s)
Tanaka Y, Kanazawa M, Kano M, Morishita J, Hamaguchi T, Van Oudenhove L, Ly HG, Dupont P, Tack J, Yamaguchi T, Yanai K, Tashiro M, Fukudo S.
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Journal Title
PLoS One
Volume: 11
Issue: 7
Pages: 1-13
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Corticotropin-Releasing Hormone Receptor 2 Gene Variants in Irritable Bowel Syndrome.2016
Author(s)
Komuro H, Sato N, Sasaki A, Suzuki N, Kano M, Tanaka Y, Yamaguchi-Kabata Y, Kanazawa M, Warita H, Aoki M, Fukudo S.
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Journal Title
PLoS One
Volume: 11
Issue: 1
Pages: e0147817-e0147817
DOI
Related Report
Peer Reviewed / Open Access
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