Hypothalamic-Pituitary-Adrenal Axis and Brain Activity in IBS

• Project/Area Number: 26870039
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurophysiology / General neuroscience; General internal medicine(including psychosomatic medicine)
• Research Institution: Tohoku University
• Principal Investigator: Tanaka Yukari 東北大学, 東北メディカル・メガバンク機構, 助教 (50721453)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 過敏性腸症候群 / 脳腸相関 / 自律神経活動 / 副腎皮質刺激ホルモン放出ホルモン / ストレス / 自律神経 / 神経内分泌 / ストレス関連ホルモン / 心拍変動 / ストレス科学 / 消化器内科学 / 神経科学 / 心身医学

Outline of Final Research Achievements

Corticotropin-releasing hormone (CRH) mediates stress responses in the brain-gut axis. Exogenous CRH differentially sensitizes brain regions of the emotional-arousal circuitry within the visceral pain matrix to colorectal distention and synergetic activation of noradrenergic function in IBS patients and healthy individuals. Administration of CRH also modulates the autonomic nervous system in response to colorectal distention. The relationship between HPA-sympathoadrenal responses and CRH levels during colorectal distention differs between patients with IBS and controls. Modulation of adrenal gland activity in response to ACTH stimulation may contribute to the brain-gut pathophysiology characteristic of IBS.

Research Products

• [Int'l Joint Research] KU Leuven(Belgium)
• [Int'l Joint Research] The University of North Carolina(米国)
• [Int'l Joint Research] KU Leuven(Belgium)
• [Journal Article] Increased postprandial colonic motility and autonomic nervous system activity in patients with irritable bowel syndrome: A prospective study. (2018)
  • Author(s): Tanaka Y, Kanazawa M, Palsson OS, Van Tilburg MA, Gangarosa LM, Fukudo S, Drossman DA, Whitehead WE.
  • Journal Title: J Neurogastroenterol Motil Volume: 24 Issue: 1 Pages: 87-95
  • DOI: 10.5056/jnm16216
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Differential activation in amygdala and plasma noradrenaline during colorectal distention by administration of corticotropin-releasing hormone between healthy individuals and patients with irritable bowel syndrome. (2016)
  • Author(s): Tanaka Y, Kanazawa M, Kano M, Morishita J, Hamaguchi T, Van Oudenhove L, Ly HG, Dupont P, Tack J, Yamaguchi T, Yanai K, Tashiro M, Fukudo S.
  • Journal Title: PLoS One Volume: 11 Issue: 7 Pages: 1-13
  • DOI: 10.1371/journal.pone.0157347
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Associations between Single-Nucleotide Polymorphisms in Corticotropin-Releasing Hormone-Related Genes and Irritable Bowel Syndrome. (2016)
  • Author(s): Sasaki A, Sato N, Suzuki N, Kano M, Tanaka Y, Kanazawa M, Aoki M, Fukudo S.
  • Journal Title: PLoS One Volume: 11 Issue: 2 Pages: e0149322-e0149322
  • DOI: 10.1371/journal.pone.0149322
  • Peer Reviewed / Open Access
• [Journal Article] Corticotropin-Releasing Hormone Receptor 2 Gene Variants in Irritable Bowel Syndrome. (2016)
  • Author(s): Komuro H, Sato N, Sasaki A, Suzuki N, Kano M, Tanaka Y, Yamaguchi-Kabata Y, Kanazawa M, Warita H, Aoki M, Fukudo S.
  • Journal Title: PLoS One Volume: 11 Issue: 1 Pages: e0147817-e0147817
  • DOI: 10.1371/journal.pone.0147817
  • Peer Reviewed / Open Access
• [Journal Article] 【Evidence Update 2016 最新の薬物治療のエビデンスを付加的に利用する】 エキスパートが注目する最新エビデンスをアップデート! 過敏性腸症候群治療薬(解説/特集) (2016)
  • Author(s): 田中由佳里
  • Journal Title: 薬局 Volume: 67 Pages: 63-65
• [Journal Article] 慢性疼痛 脳腸相関と内臓知覚のメカニズム (2016)
  • Author(s): 田中由佳里
  • Journal Title: 子どもの心とからだ Volume: 24 Pages: 182-182
• [Journal Article] Identifying Functionally Meaningful Biomarkers in Irritable Bowel Syndrome (2015)
  • Author(s): Sugai C, Tanaka Y, Kanazawa M, Morishita J, Kano M, Shoji T, Endo Y, Fukudo S
  • Journal Title: GASTROENTEROLOGY Volume: 148
  • Peer Reviewed
• [Journal Article] Altered Relation of Autonomic Response and Pituitary-Adrenal Response During Colorectal Distention With Corticotropin-Releasing Hormone in Irritable Bowel Syndrome (2015)
  • Author(s): Tanaka Y, Morishita, J, Kanazawa M, Tashiro M, Fukudo S
  • Journal Title: GASTROENTEROLOGY Volume: 148
  • Peer Reviewed
• [Journal Article] Does Camostat Mesilate Improve Abdominal Symptoms and Visceral Pain Sensitivity in Patients with Irritable Bowel Syndrome (IBS)? (2015)
  • Author(s): Kanazawa M, Morishita J, Tanaka Y, Inooka K, Kano M, Hisamichi K, Mano N, Fukudo S (Fukudo, Shin)
  • Journal Title: DIGESTION Volume: 91 Pages: 92-92
  • Peer Reviewed
• [Journal Article] Injection of corticotropin-releasing hormone into the amygdala aggravates visceral nociception and induces noradrenaline release in rats. (2015)
  • Author(s): Su J, Tanaka Y, Muratsubaki T, Kano M, Kanazawa M, Fukudo S.
  • Journal Title: Neurogastroenterol Motil Volume: 27 Issue: 1 Pages: 30-39
  • DOI: 10.1111/nmo.12462
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Searching for biological factors in a biopsychosocial model of irritable bowel syndrome (2017)
  • Author(s): Yukari Tanaka
  • Organizer: UEGW2018 (欧州消化器病学会)(招待講演)(国際学会)
  • Int'l Joint Research / Invited
• [Presentation] 心と体の声に耳を傾けてみよう (2015)
  • Author(s): 田中 由佳里
  • Organizer: 仙台市役所メンタルヘルス講演会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2015-11-04
  • Invited
• [Presentation] 脳腸相関と内臓知覚のメカニズム (2015)
  • Author(s): 田中 由佳里
  • Organizer: 第33回日本小児心身医学会学術集会
  • Place of Presentation: 東京都渋谷区
  • Year and Date: 2015-09-11
  • Invited
• [Presentation] Altered Relation of Autonomic Response and Pituitary-Adrenal Response During Colorectal Distention With Corticotropin-Releasing Hormone in Irritable Bowel Syndrome (2015)
  • Author(s): 田中 由佳里
  • Organizer: Digestive Disease Week 2015
  • Place of Presentation: ワシントンDC、米国
  • Year and Date: 2015-05-18
  • Int'l Joint Research
• [Presentation] Altered Relation of Autonomic Response and Pituitary-Adrenal Response during Colorectal Distention with Corticotropin-Releasing Hormone in Irritable Bowel Syndrome (2015)
  • Author(s): Yukari Tanaka
  • Organizer: Digestive Disease Week 2015 （米国消化器病学会）
  • Place of Presentation: Washington DC (USA)
  • Year and Date: 2015-05-18
• [Book] Gノート 2017年6月号 (2017)
  • Author(s): 木村 琢磨（編）、田中由佳里
  • Total Pages: 166
  • Publisher: 羊土社
  • ISBN: 9784758123228
• [Book] Annual Review 2015 (2015)
  • Author(s): 田中 由佳里、福土 審
  • Total Pages: 7
  • Publisher: 中外医学社