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Pathological and genomic study of ovarian mucinous adenocarcinoma

Research Project

Project/Area Number 26870129
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Human pathology
Research InstitutionAkita University

Principal Investigator

MAEDA DAICHI  秋田大学, 医学(系)研究科(研究院), 准教授 (30585500)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords卵巣粘液性腫瘍
Outline of Final Research Achievements

We investigated ovarian mucinous tumor focusing on the difference between gastrointestinal-type and endocervical-type mucinous tumors. With regard to endocervical-type mucinous tumors, we investigated ARID1A alterations which is known to play an oncogenic role in endometriosis-associated ovarian cancer. As a result, loss of ARID1A expression, which suggests presence of mutation, was observed in a subset of endocervical-type mucinous borderline tumor. The loss of ARID1A expression was also observed in adjacent endometriotic epithelium. This finding suggest that ARID1A is involved in tumorigenesis of endocervical-type mucinous tumors. Further, ARID1A alteration occur in an early phase of its tumorigenesis.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (2 results) Book (2 results)

  • [Journal Article] SKAP2 Promotes Podosome Formation to Facilitate Tumor-Associated Macrophage Infiltration and Metastatic Progression.2016

    • Author(s)
      Tanaka M, Shimamura S, Kuriyama S, Maeda D, Goto A, Aiba N.
    • Journal Title

      Cancer Res.

      Volume: 76 Pages: 358-369

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hunner-Type (Classic) Interstitial Cystitis: A Distinct Inflammatory Disorder Characterized by Pancystitis, with Frequent Expansion of Clonal B-Cells and Epithelial Denudation.2015

    • Author(s)
      Maeda D, Akiyama Y, Morikawa T, Kunita A, Ota Y, Katoh H, Niimi A, Nomiya A, Ishikawa S, Goto A, Igawa Y, Fukayama M, Homma Y.
    • Journal Title

      PLos One

      Volume: 10 Issue: 11 Pages: 1-16

    • DOI

      10.1371/journal.pone.0143316

    • NAID

      120007089047

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prognostic importance of CDK4/6-specific activity as a predictive marker for recurrence in patients with endometrial cancer, with or without adjuvant chemotherapy.2015

    • Author(s)
      keda Y, Oda K, Ishihara H, Wada-Hiraike O, Miyasaka A, Kashiyama T, Inaba K, Fukuda T, Sone K, Matsumoto Y, Arimoto T, Maeda D, Ikemura M, Fukayama M, Kawana K, Yano T, Aoki D, Osuga Y, Fujii T.
    • Journal Title

      Br J Cancer

      Volume: 113 Issue: 10 Pages: 1477-1483

    • DOI

      10.1038/bjc.2015.369

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Agr2 mediates paracrine effects on stromal fibroblasts that promote invasion by gastric signet-ring carcinoma cells2015

    • Author(s)
      Tsuji T., Satoyoshi R., Aiba N., Kubo T., Yanagihara K., Maeda D., Goto A., Ishikawa K., Yashiro M., Tanaka M
    • Journal Title

      Cancer Research

      Volume: 75 Issue: 2 Pages: 356-366

    • DOI

      10.1158/0008-5472.can-14-1693

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Huge pyogenic cervical cyst with endometriosis, developing 13 years after myomectomy at the lower uterine segment: a case report.2014

    • Author(s)
      Oda K, Ikeda Y, Maeda D, Arimoto T, Kawana K, Fukayama M, Osuga Y, Fujii T
    • Journal Title

      BMC Womens Health

      Volume: 14 Issue: 1 Pages: 104-104

    • DOI

      10.1186/1472-6874-14-104

    • NAID

      120007089070

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Xanthogranulomatous inflammation of the perimetrium with infiltration into the uterine myometrium in a postmenopausal woman: a case report.2014

    • Author(s)
      Inoue T, Oda K, Arimoto T, Samejima T, Takazawa Y, Maeda D, Fukayama M, Kawana K, Osuga Y, Fujii T.
    • Journal Title

      BMC Womens Health

      Volume: 14 Issue: 1 Pages: 82-82

    • DOI

      10.1186/1472-6874-14-82

    • NAID

      120007089071

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Utility of Claudin-18 and p16 Immunohistochemistry for distinguishing Gastric-type Adenocarcinoma from Other Subtypes of Cervical Adenocarcinoma2015

    • Author(s)
      Daichi Maeda
    • Organizer
      104th Annual Meeting of USCAP
    • Place of Presentation
      Boston, U.S.A.
    • Year and Date
      2015-03-21 – 2015-03-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Hunner type (Classic) Interstitial Cystitis is a Distinct Inflammatory Disorder Characterized by Epithelial Denudation and Pancystitis with Focal Expansion of Clonal B-Cells2015

    • Author(s)
      Daichi Maeda, Yoshiyuki Akiyama
    • Organizer
      104th Annual Meeting of USCAP
    • Place of Presentation
      Boston, U.S.A.
    • Year and Date
      2015-03-21 – 2015-03-27
    • Related Report
      2014 Research-status Report
  • [Book] 病理と臨床・臨時増刊号「免疫組織化学」2014

    • Author(s)
      前田大地
    • Total Pages
      10
    • Publisher
      文光堂
    • Related Report
      2014 Research-status Report
  • [Book] 腫瘍病理鑑別診断アトラス 子宮体癌2014

    • Author(s)
      前田大地
    • Total Pages
      11
    • Publisher
      文光堂
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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