Pathological and genomic study of ovarian mucinous adenocarcinoma
| Project/Area Number |
26870129
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
Human pathology
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| Research Institution | Akita University |
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Principal Investigator |
MAEDA DAICHI 秋田大学, 医学(系)研究科(研究院), 准教授 (30585500)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 卵巣粘液性腫瘍 |
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| Outline of Final Research Achievements |
We investigated ovarian mucinous tumor focusing on the difference between gastrointestinal-type and endocervical-type mucinous tumors. With regard to endocervical-type mucinous tumors, we investigated ARID1A alterations which is known to play an oncogenic role in endometriosis-associated ovarian cancer. As a result, loss of ARID1A expression, which suggests presence of mutation, was observed in a subset of endocervical-type mucinous borderline tumor. The loss of ARID1A expression was also observed in adjacent endometriotic epithelium. This finding suggest that ARID1A is involved in tumorigenesis of endocervical-type mucinous tumors. Further, ARID1A alteration occur in an early phase of its tumorigenesis.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Hunner-Type (Classic) Interstitial Cystitis: A Distinct Inflammatory Disorder Characterized by Pancystitis, with Frequent Expansion of Clonal B-Cells and Epithelial Denudation.2015
Author(s)
Maeda D, Akiyama Y, Morikawa T, Kunita A, Ota Y, Katoh H, Niimi A, Nomiya A, Ishikawa S, Goto A, Igawa Y, Fukayama M, Homma Y.
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Journal Title
PLos One
Volume: 10
Issue: 11
Pages: 1-16
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Prognostic importance of CDK4/6-specific activity as a predictive marker for recurrence in patients with endometrial cancer, with or without adjuvant chemotherapy.2015
Author(s)
keda Y, Oda K, Ishihara H, Wada-Hiraike O, Miyasaka A, Kashiyama T, Inaba K, Fukuda T, Sone K, Matsumoto Y, Arimoto T, Maeda D, Ikemura M, Fukayama M, Kawana K, Yano T, Aoki D, Osuga Y, Fujii T.
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Journal Title
Br J Cancer
Volume: 113
Issue: 10
Pages: 1477-1483
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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