Pathological and genomic study of ovarian mucinous adenocarcinoma

• Project/Area Number: 26870129
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology; Human pathology
• Research Institution: Akita University
• Principal Investigator: MAEDA DAICHI 秋田大学, 医学(系)研究科(研究院), 准教授 (30585500)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 卵巣粘液性腫瘍

Outline of Final Research Achievements

We investigated ovarian mucinous tumor focusing on the difference between gastrointestinal-type and endocervical-type mucinous tumors. With regard to endocervical-type mucinous tumors, we investigated ARID1A alterations which is known to play an oncogenic role in endometriosis-associated ovarian cancer. As a result, loss of ARID1A expression, which suggests presence of mutation, was observed in a subset of endocervical-type mucinous borderline tumor. The loss of ARID1A expression was also observed in adjacent endometriotic epithelium. This finding suggest that ARID1A is involved in tumorigenesis of endocervical-type mucinous tumors. Further, ARID1A alteration occur in an early phase of its tumorigenesis.

Research Products

• [Journal Article] SKAP2 Promotes Podosome Formation to Facilitate Tumor-Associated Macrophage Infiltration and Metastatic Progression. (2016)
  • Author(s): Tanaka M, Shimamura S, Kuriyama S, Maeda D, Goto A, Aiba N.
  • Journal Title: Cancer Res. Volume: 76 Pages: 358-369
  • Peer Reviewed
• [Journal Article] Hunner-Type (Classic) Interstitial Cystitis: A Distinct Inflammatory Disorder Characterized by Pancystitis, with Frequent Expansion of Clonal B-Cells and Epithelial Denudation. (2015)
  • Author(s): Maeda D, Akiyama Y, Morikawa T, Kunita A, Ota Y, Katoh H, Niimi A, Nomiya A, Ishikawa S, Goto A, Igawa Y, Fukayama M, Homma Y.
  • Journal Title: PLos One Volume: 10 Issue: 11 Pages: 1-16
  • DOI: 10.1371/journal.pone.0143316
  • NAID: 120007089047
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic importance of CDK4/6-specific activity as a predictive marker for recurrence in patients with endometrial cancer, with or without adjuvant chemotherapy. (2015)
  • Author(s): keda Y, Oda K, Ishihara H, Wada-Hiraike O, Miyasaka A, Kashiyama T, Inaba K, Fukuda T, Sone K, Matsumoto Y, Arimoto T, Maeda D, Ikemura M, Fukayama M, Kawana K, Yano T, Aoki D, Osuga Y, Fujii T.
  • Journal Title: Br J Cancer Volume: 113 Issue: 10 Pages: 1477-1483
  • DOI: 10.1038/bjc.2015.369
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Agr2 mediates paracrine effects on stromal fibroblasts that promote invasion by gastric signet-ring carcinoma cells (2015)
  • Author(s): Tsuji T., Satoyoshi R., Aiba N., Kubo T., Yanagihara K., Maeda D., Goto A., Ishikawa K., Yashiro M., Tanaka M
  • Journal Title: Cancer Research Volume: ７５ Issue: 2 Pages: 356-366
  • DOI: 10.1158/0008-5472.can-14-1693
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Huge pyogenic cervical cyst with endometriosis, developing 13 years after myomectomy at the lower uterine segment: a case report. (2014)
  • Author(s): Oda K, Ikeda Y, Maeda D, Arimoto T, Kawana K, Fukayama M, Osuga Y, Fujii T
  • Journal Title: BMC Womens Health Volume: 14 Issue: 1 Pages: 104-104
  • DOI: 10.1186/1472-6874-14-104
  • NAID: 120007089070
  • Peer Reviewed / Open Access
• [Journal Article] Xanthogranulomatous inflammation of the perimetrium with infiltration into the uterine myometrium in a postmenopausal woman: a case report. (2014)
  • Author(s): Inoue T, Oda K, Arimoto T, Samejima T, Takazawa Y, Maeda D, Fukayama M, Kawana K, Osuga Y, Fujii T.
  • Journal Title: BMC Womens Health Volume: 14 Issue: 1 Pages: 82-82
  • DOI: 10.1186/1472-6874-14-82
  • NAID: 120007089071
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Utility of Claudin-18 and p16 Immunohistochemistry for distinguishing Gastric-type Adenocarcinoma from Other Subtypes of Cervical Adenocarcinoma (2015)
  • Author(s): Daichi Maeda
  • Organizer: 104th Annual Meeting of USCAP
  • Place of Presentation: Boston, U.S.A.
  • Year and Date: 2015-03-21 – 2015-03-27
• [Presentation] Hunner type (Classic) Interstitial Cystitis is a Distinct Inflammatory Disorder Characterized by Epithelial Denudation and Pancystitis with Focal Expansion of Clonal B-Cells (2015)
  • Author(s): Daichi Maeda, Yoshiyuki Akiyama
  • Organizer: 104th Annual Meeting of USCAP
  • Place of Presentation: Boston, U.S.A.
  • Year and Date: 2015-03-21 – 2015-03-27
• [Book] 病理と臨床・臨時増刊号「免疫組織化学」 (2014)
  • Author(s): 前田大地
  • Total Pages: 10
  • Publisher: 文光堂
• [Book] 腫瘍病理鑑別診断アトラス 子宮体癌 (2014)
  • Author(s): 前田大地
  • Total Pages: 11
  • Publisher: 文光堂