| Project/Area Number |
26870166
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
Nano/Microsystems
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Kushiro Keiichiro 東京大学, 工学(系)研究科(研究院), 助教 (90632539)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAI Madoka 東京大学, 大学院工学系研究科, 教授 (40287975)
RYO Akihide 横浜市立大学, 大学院医学研究科, 教授 (20363814)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | マイクロトポグラフィー / ハイドロゲル / 細胞移動 / 癌 / 癌転移 / microtopography / directed cell migration |
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| Outline of Final Research Achievements |
During metastasis, cancer cells migrate through various microstructures in the body, but the mechanical influence of these structures or the underlying mechanism have not been clarified. From previous works of the representative, it was shown that microgroove structures can enhance the motility of normal epithelial cells. Here, the possibility of controlling the migration of cancer cells using such "topography effect" was investigated. It was found that various cancer cells are unable to form stable cytoskeleton, and thus receive less topographical cues, resulting in interesting behaviors of cancer cells, such as the climbing of cancerous cells over the walls, which was not seen for normal cells. These observations are important discoveries in the context of cancer metastasis because they suggest that cancer cells can ignore the mechanical signals from the microstructures within the body and migrate to any part of the body, possibly facilitating their escape from immune cells.
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