System-based drug discovery database using partial least square regression

• Project/Area Number: 26870175
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery; Tumor therapeutics
• Research Institution: Juntendo University
• Principal Investigator: MOGUSHI Kaoru 順天堂大学, 医学(系)研究科(研究院), 助教 (60569292)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 肝細胞癌 / 遺伝子発現解析 / バイオインフォマティクス / 部分最小二乗回帰 / 多変量解析 / シグナル伝達 / マイクロアレイ

Outline of Final Research Achievements

Hepatocellular carcinoma (HCC) is one of the most common cause of cancer-related death in the world. There is an urgent need for novel drug other than sorafenib for treatment of HCC. In this study, we aimed to develop multi-dimensional database for system-based drug discovery in HCC using various clinicopathological characteristics and gene expression profiles obtained from cancer tissues. Partial least square regression (PLSR) was used to analyze complex correlation between gene expression patterns and clinicopathological features.

Research Products

• [Journal Article] ARID2 modulates DNA damage response in human hepatocellular carcinoma cells. (2017)
  • Author(s): Oba A, Shimada S, Akiyama Y, Nishikawaji T, Mogushi K, Ito H, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Asahara H, Kaida A, Miura M, Tanabe M, Tanaka S.
  • Journal Title: Journal of Hepatology Volume: in press Issue: 5 Pages: 942-951
  • DOI: 10.1016/j.jhep.2016.12.026
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Acquired resistance with epigenetic alterations under long-term anti-angiogenic therapy for hepatocellular carcinoma. (2017)
  • Author(s): Ohata Y, Akiyama Y, Shimada S, Mogushi K, Nakao K, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Tanabe M, Tanaka S.
  • Journal Title: Molecular Cancer Therapeutics Volume: in press Issue: 6 Pages: 1155-1165
  • DOI: 10.1158/1535-7163.mct-16-0728
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] CD73 as a therapeutic target for pancreatic neuroendocrine tumor stem cells. (2016)
  • Author(s): Katsuta, E., Tanaka, S., Mogushi, K., Shimada, S., Akiyama, Y., Aihara, A., Matsumura, S., Mitsunori, Y., Ban, D., Ochiai, T., Kudo, A., Fukamachi, H., Tanaka, H., Nakayama, K., Arii, S., Tanabe, M.
  • Journal Title: Int. J. Oncol. Volume: 48 Issue: 2 Pages: 657-669
  • DOI: 10.3892/ijo.2015.3299
  • Peer Reviewed / Open Access
• [Journal Article] CD73 as a therapeutic target for pancreatic neuroendocrine tumor stem cells. (2016)
  • Author(s): Katsuta E, Tanaka S, Mogushi K, Shimada S, Akiyama Y, Aihara A, Matsumura S, Mitsunori Y, Ban D, Ochiai T, Kudo A, Fukamachi H, Tanaka H, Nakayama K, Arii S, Tanabe M.
  • Journal Title: International Journal of Oncology Volume: 48 Issue: 9 Pages: 657-69
  • DOI: 10.1007/s00535-015-1159-8
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Distinct clinicopathological phenotype of hepatocellular carcinoma with EOB-MRI hyperintensity: association with gene expression signature (2015)
  • Author(s): Miura T, Ban D, Tanaka S, Mogushi K, Kudo A, Matsumura S, Mitsunori Y, Ochiai T, Tanaka H, Tanabe M.
  • Journal Title: Am J Surg. Volume: 210 Issue: 3 Pages: 561-569
  • DOI: 10.1016/j.amjsurg.2015.03.027
  • Peer Reviewed
• [Journal Article] Prognostic significance of Traf2-and Nck- interacting kinase (TNIK) in colorectal cancer. (2015)
  • Author(s): Takahashi H, Ishikawa T, Ishiguro M, Okazaki S, Mogushi K, Kobayashi H, Iida S, Mizushima H, Tanaka H, Uetake H, Sugihara K.
  • Journal Title: BMC Cancer Volume: 15 Issue: 1 Pages: 794-794
  • DOI: 10.1186/s12885-015-1783-y
  • Peer Reviewed / Open Access
• [Journal Article] CHCHD2 mutations in autosomal dominant late-onset Parkinson’s disease: a genome-wide linkage and sequencing study. (2015)
  • Author(s): Funayama M, Ohe K, Amo T, Furuya N, Yamaguchi J, Saiki S, Yuanzhe L, Ogaki K, Ando M, Yoshinon H, Tomiyama H, Nishioka K, Hasegawa K, Saiki H, Satake W, Mogushi K, Sasaki R, Kokubo Y, Kuzuhara S, Toda T, Mizuno Y, Uchiyama Y, Ohno K, Hattori N.
  • Journal Title: Lancet Neurol Volume: 14 Issue: 3 Pages: 274-282
  • DOI: 10.1016/s1474-4422(14)70266-2
  • Peer Reviewed / Open Access
• [Journal Article] Age-related clinicopathological and molecular features of patients received curative hepatectomy for hepatocellular carcinoma. (2014)
  • Author(s): Katsuta E, Tanaka S, Mogushi K, Matsumura S, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Tanaka H, Tanabe M, Arii S.
  • Journal Title: American Journal of Surgery Volume: 208(3) Issue: 3 Pages: 450-456
  • DOI: 10.1016/j.amjsurg.2014.01.015
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Involvement of MAP3K8 and miR-17-5p in poor virologic response to interferon-based combination therapy for chronic hepatitis C (2014)
  • Author(s): Tsubota A, Mogushi K, Aizaki H, Miyaguchi K, Nagatsuma K, Matsudaira H, Kushida T, Furihata T, Tanaka H, Matsuura T.
  • Journal Title: PLoS One Volume: 9 Issue: 5 Pages: e97078-e97078
  • DOI: 10.1371/journal.pone.0097078
  • Peer Reviewed / Open Access
• [Journal Article] Mitochondrial metabolism in the noncancerous liver determine the occurrence of hepatocellular carcinoma: a prospective study. (2014)
  • Author(s): Kudo A, Mogushi K, Takayama T, Matsumura S, Ban D, Irie T, Ochiai T, Nakamura N, Tanaka H, Anzai N, Sakamoto M, Tanaka S, Arii S.
  • Journal Title: J Gastroenterol. Volume: 49 Issue: 3 Pages: 502-10
  • DOI: 10.1007/s00535-013-0791-4
  • Peer Reviewed
• [Presentation] Gene expression analysis and cancer signaling networks (2017)
  • Author(s): Kaoru Mogushi
  • Organizer: International Symposium on BioComplexity
  • Place of Presentation: B-Conプラザ (別府)
  • Year and Date: 2017-01-18
  • Int'l Joint Research
• [Remarks] 順天堂大学 研究者情報データベース
  • URL: http://www.juntendo.ac.jp/graduate/kenkyudb/search/achievement.php?MID=5240
• [Remarks] 順天堂大学 研究者情報データベース
  • URL: https://www.juntendo.ac.jp/graduate/kenkyudb/search/researcher.php?MID=5240