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System-based drug discovery database using partial least square regression

Research Project

Project/Area Number 26870175
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Tumor therapeutics
Research InstitutionJuntendo University

Principal Investigator

MOGUSHI Kaoru  順天堂大学, 医学(系)研究科(研究院), 助教 (60569292)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords肝細胞癌 / 遺伝子発現解析 / バイオインフォマティクス / 部分最小二乗回帰 / 多変量解析 / シグナル伝達 / マイクロアレイ
Outline of Final Research Achievements

Hepatocellular carcinoma (HCC) is one of the most common cause of cancer-related death in the world. There is an urgent need for novel drug other than sorafenib for treatment of HCC. In this study, we aimed to develop multi-dimensional database for system-based drug discovery in HCC using various clinicopathological characteristics and gene expression profiles obtained from cancer tissues. Partial least square regression (PLSR) was used to analyze complex correlation between gene expression patterns and clinicopathological features.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (13 results)

All 2017 2016 2015 2014 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 6 results,  Acknowledgement Compliant: 4 results) Presentation (1 results) (of which Int'l Joint Research: 1 results) Remarks (2 results)

  • [Journal Article] ARID2 modulates DNA damage response in human hepatocellular carcinoma cells.2017

    • Author(s)
      Oba A, Shimada S, Akiyama Y, Nishikawaji T, Mogushi K, Ito H, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Asahara H, Kaida A, Miura M, Tanabe M, Tanaka S.
    • Journal Title

      Journal of Hepatology

      Volume: in press Issue: 5 Pages: 942-951

    • DOI

      10.1016/j.jhep.2016.12.026

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Acquired resistance with epigenetic alterations under long-term anti-angiogenic therapy for hepatocellular carcinoma.2017

    • Author(s)
      Ohata Y, Akiyama Y, Shimada S, Mogushi K, Nakao K, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Tanabe M, Tanaka S.
    • Journal Title

      Molecular Cancer Therapeutics

      Volume: in press Issue: 6 Pages: 1155-1165

    • DOI

      10.1158/1535-7163.mct-16-0728

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CD73 as a therapeutic target for pancreatic neuroendocrine tumor stem cells.2016

    • Author(s)
      Katsuta, E., Tanaka, S., Mogushi, K., Shimada, S., Akiyama, Y., Aihara, A., Matsumura, S., Mitsunori, Y., Ban, D., Ochiai, T., Kudo, A., Fukamachi, H., Tanaka, H., Nakayama, K., Arii, S., Tanabe, M.
    • Journal Title

      Int. J. Oncol.

      Volume: 48 Issue: 2 Pages: 657-669

    • DOI

      10.3892/ijo.2015.3299

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD73 as a therapeutic target for pancreatic neuroendocrine tumor stem cells.2016

    • Author(s)
      Katsuta E, Tanaka S, Mogushi K, Shimada S, Akiyama Y, Aihara A, Matsumura S, Mitsunori Y, Ban D, Ochiai T, Kudo A, Fukamachi H, Tanaka H, Nakayama K, Arii S, Tanabe M.
    • Journal Title

      International Journal of Oncology

      Volume: 48 Issue: 9 Pages: 657-69

    • DOI

      10.1007/s00535-015-1159-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Distinct clinicopathological phenotype of hepatocellular carcinoma with EOB-MRI hyperintensity: association with gene expression signature2015

    • Author(s)
      Miura T, Ban D, Tanaka S, Mogushi K, Kudo A, Matsumura S, Mitsunori Y, Ochiai T, Tanaka H, Tanabe M.
    • Journal Title

      Am J Surg.

      Volume: 210 Issue: 3 Pages: 561-569

    • DOI

      10.1016/j.amjsurg.2015.03.027

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer2015

    • Author(s)
      Takahashi H, Ishikawa T, Ishiguro M, Okazaki S, Mogushi K, Kobayashi H, Iida S, Mizushima H, Tanaka H, Uetake H, Sugihara K.
    • Journal Title

      BMC Cancer

      Volume: 15 Issue: 1 Pages: 794-794

    • DOI

      10.1186/s12885-015-1783-y

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] CHCHD2 mutations in autosomal dominant late-onset Parkinson’s disease: a genome-wide linkage and sequencing study.2015

    • Author(s)
      Funayama M, Ohe K, Amo T, Furuya N, Yamaguchi J, Saiki S, Yuanzhe L, Ogaki K, Ando M, Yoshinon H, Tomiyama H, Nishioka K, Hasegawa K, Saiki H, Satake W, Mogushi K, Sasaki R, Kokubo Y, Kuzuhara S, Toda T, Mizuno Y, Uchiyama Y, Ohno K, Hattori N.
    • Journal Title

      Lancet Neurol

      Volume: 14 Issue: 3 Pages: 274-282

    • DOI

      10.1016/s1474-4422(14)70266-2

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Age-related clinicopathological and molecular features of patients received curative hepatectomy for hepatocellular carcinoma.2014

    • Author(s)
      Katsuta E, Tanaka S, Mogushi K, Matsumura S, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Tanaka H, Tanabe M, Arii S.
    • Journal Title

      American Journal of Surgery

      Volume: 208(3) Issue: 3 Pages: 450-456

    • DOI

      10.1016/j.amjsurg.2014.01.015

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Involvement of MAP3K8 and miR-17-5p in poor virologic response to interferon-based combination therapy for chronic hepatitis C2014

    • Author(s)
      Tsubota A, Mogushi K, Aizaki H, Miyaguchi K, Nagatsuma K, Matsudaira H, Kushida T, Furihata T, Tanaka H, Matsuura T.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 5 Pages: e97078-e97078

    • DOI

      10.1371/journal.pone.0097078

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitochondrial metabolism in the noncancerous liver determine the occurrence of hepatocellular carcinoma: a prospective study.2014

    • Author(s)
      Kudo A, Mogushi K, Takayama T, Matsumura S, Ban D, Irie T, Ochiai T, Nakamura N, Tanaka H, Anzai N, Sakamoto M, Tanaka S, Arii S.
    • Journal Title

      J Gastroenterol.

      Volume: 49 Issue: 3 Pages: 502-10

    • DOI

      10.1007/s00535-013-0791-4

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Gene expression analysis and cancer signaling networks2017

    • Author(s)
      Kaoru Mogushi
    • Organizer
      International Symposium on BioComplexity
    • Place of Presentation
      B-Conプラザ (別府)
    • Year and Date
      2017-01-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 順天堂大学 研究者情報データベース

    • URL

      http://www.juntendo.ac.jp/graduate/kenkyudb/search/achievement.php?MID=5240

    • Related Report
      2016 Annual Research Report
  • [Remarks] 順天堂大学 研究者情報データベース

    • URL

      https://www.juntendo.ac.jp/graduate/kenkyudb/search/researcher.php?MID=5240

    • Related Report
      2015 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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