An investigation for involvement of TET1 gene in tumorigenesis

• Project/Area Number: 26870222
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry; General medical chemistry
• Research Institution: Kanazawa University
• Principal Investigator: Tange Shoichiro 金沢大学, 医学系, 博士研究員 (40571211)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: DNA脱メチル化

Outline of Final Research Achievements

On the other hand there have been many reports of the relationship between the molecular machinery of DNA methylation and malignant tumor, the relationship of DNA demethylation mechanism and cancer remains unclear. Upon starting the research, we have found that the transcriptional level of TET1 (Ten-eleven translocation 1) gene, a member of active DNA demethylation pathway, is not only upregulated in some cell lines but also downregulated in other cancer cell lines. We found the cellular environment inducing transcriptional repression or upregulation of TET1 gene and the candidate of TET1 target genes.