Objective assessments of abnormal multimodal information processing in autism spectrum disorder; a magnetoencephalographic study

• Project/Area Number: 26870333
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Educational psychology; Basic / Social brain science
• Research Institution: Osaka University
• Principal Investigator: Matsuzaki Junko 大阪大学, 連合小児発達学研究科, 特任講師 (00634172)
• Research Collaborator: OGAWA Rei 大阪大学, 大学院 連合小児発達学研究科, 大学院生 ; TANIGAWA Junpei 大阪大学, 大学院 医学系研究科 小児科学, 大学院生 ; HANAIE Ryuzo 大阪大学, 大学院 連合小児発達学研究科, 助教 ; YAMAMOTO Tomoka 大阪大学, 大学院 連合小児発達学研究科附属子どものこころの分子統御機構研究センター, 助教 ; TOMINAGA Koji 大阪大学, 大学院 連合小児発達学研究科, 助教 ; SHIMONO Kuriko (KAGITANI Kuriko) 大阪大学, 大学院 連合小児発達学研究科, 講師 ; MOHRI Ikuko 大阪大学, 大学院 連合小児発達学研究科, 准教授 ; HIRATA Masayuki 大阪大学, 大学院 医学系研究科 国際医工情報センター臨床神経医工学, 教授 ; TANIIKE Masako 大阪大学, 大学院 連合小児発達学研究科, 教授
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 自閉スペクトラム症 / 脳磁図 / 感覚優位性 / 自閉症スペクトラム / 脳機能 / 感覚特性 / 感覚

Outline of Final Research Achievements

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized primarily by impaired social and communication skills, and by repetitive and stereotyped behavior. Although difficulties and variety in sensory and language processing have been reported in patients with ASD, the neurophysiological mechanisms remain unknown. The aim of this study is to clarify the Japanese hiragana word processing (unimodal: reading, listening, multimodal: reading/listening) in children with ASD and developing objective assessments of their abnormalities, using magnetoencephalography. We found that abnormal cortical activations of unimodal and multimodal information processing in children with ASD, even though they did not have any specific language impairment.

Research Products

• [Presentation] Cortical activation for reading semantic words in children with autism spectrum disorder: A magnetoencephalographic study (2016)
  • Author(s): Rei Ogawa, Kuriko Kagitani-Shimono, Junko Matsuzaki, Junpei Tanigawa, Ryuzo Hanaie, Tomoka Yamamoto, Koji Tominaga, Masayuki Hirata, Ikuko Mohri, Masako Taniike
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego(米国)
  • Year and Date: 2016-11-12
  • Int'l Joint Research