| Project/Area Number |
26870341
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
Neurochemistry/Neuropharmacology
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| Research Institution | University of Fukui (2016)
National Institutes of Biomedical Innovation, Health and Nutrition (2014-2015) |
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Principal Investigator |
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| Research Collaborator |
TSUJII Akira 国立研究開発法人医薬基盤・健康・栄養研究所, 細胞核輸送ダイナミクスプロジェクト
KIMOTO Chihiro 国立研究開発法人医薬基盤・健康・栄養研究所, 細胞核輸送ダイナミクスプロジェクト
HIKIDA Takatoshi 国立大学法人 京都大学, 大学院医学研究科
MORITA Makiko 国立大学法人 京都大学, 大学院医学研究科
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 神経科学 / 核-細胞質間輸送 / 精神疾患 / 核内輸送 / 核輸送 |
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| Outline of Final Research Achievements |
As humans get older, their memory and concentration will decline. However, the mechanism of memory disturbance due to aging is hardly understood. In this study, we focused on some nuclear-cytoplasmic transport factors reported as candidate factors for neuropsychiatric disorders. As the result, it was found that importin α1 (KPNA1) gene deficient mice had stress vulnerability exhibiting behavioral abnormalities due to stress load. Furthermore, it became clear that importin α is involved in the transport of new biofunctional factors.
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