Identification of stroke susceptible genes in the stroke-spontaneously hypertensive rats and evaluation of its molecular pathogenesis
| Project/Area Number |
26870376
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
Experimental pathology
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| Research Institution | Shimane University |
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Principal Investigator |
Hiroki Ohara 島根大学, 医学部, 助教 (10609225)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 脳卒中易発症高血圧自然発症ラット / コンジェニックラット / 脳卒中感受性遺伝子 / 疾患モデル / 高血圧 / 脳卒中 |
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| Outline of Final Research Achievements |
In the previous study, we showed that two genomic regions on rat chromosome (chr) 1 and 18 determines most of the stroke susceptibility under salt loading in stroke-prone spontaneously hypertensive rats (SHRSP). In the present study, we performed a microarray-based screening to identify promising candidate genes by using SHRSP, stroke-resistant SHR and two of reciprocal congenic strains (Pr1_18 and Rp1_18) covering the quantitative trait loci (QTL) on chr 1 and 18. Quantitative expression analysis for miRNA on the chr 1 QTL was also performed.
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Report
(3 results)
Research Products
(7 results)
