Hemokinin-1 mediates pruriceptive processing in the rat spinal cord
| Project/Area Number |
26870451
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine(including psychosomatic medicine)
Pain science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Hemokinin-1 / itch / scratching / [Leu11]-HK-1 / hemokinin-1 |
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| Outline of Final Research Achievements |
The present study demonstrated that the intrathecal administration of [Leu11]-HK-1 attenuated HK-1-induced scratching and the induction of scratching behavior by 5-HT or histamine, indicating that HK-1 is a neurotransmitter or neuromodulator in pruritic processing at the level of the spinal cord. And D-tryptophan (D-Trp) prolongs the duration of effective time of [Leu11]-HK-1.Therefore, it is possible that [Leu11]-HK-1 is a valuable tool for clarifying the underlying mechanism of pruritic processing,but not nociceptive processing at the spinal level.
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Report
(3 results)
Research Products
(13 results)
