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Hemokinin-1 mediates pruriceptive processing in the rat spinal cord

Research Project

Project/Area Number 26870451
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General internal medicine(including psychosomatic medicine)
Pain science
Research InstitutionUniversity of Miyazaki

Principal Investigator

Funahashi Hideki  宮崎大学, 医学部, 講師 (10404435)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsHemokinin-1 / itch / scratching / [Leu11]-HK-1 / hemokinin-1
Outline of Final Research Achievements

The present study demonstrated that the intrathecal administration of [Leu11]-HK-1 attenuated HK-1-induced scratching and the induction of scratching behavior by 5-HT or histamine, indicating that HK-1 is a neurotransmitter or neuromodulator in pruritic processing at the level of the spinal cord. And D-tryptophan (D-Trp) prolongs the duration of effective time of [Leu11]-HK-1.Therefore, it is possible that [Leu11]-HK-1 is a valuable tool for clarifying the underlying mechanism of pruritic processing,but not nociceptive processing at the spinal level.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (13 results)

All 2015 2014

All Journal Article (6 results) (of which Peer Reviewed: 4 results,  Open Access: 5 results,  Acknowledgement Compliant: 4 results) Presentation (7 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Hemokinin-1-derived peptides have antipruritic effects in rats.2015

    • Author(s)
      Funahashi H., Naono-Nakayama R., Koganemaru G., Miyahara Y., Nishimori T., Ishida Y.
    • Journal Title

      Ther. Targets Neurol. Dis.

      Volume: 2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] [Leu11]-HK-1-derived peptides with D-Trp prolong antipruriceptive effects in rats.2015

    • Author(s)
      Funahashi H., Naono-Nakayama R., Miyahara Y., Ishida Y., Nishimori T.
    • Journal Title

      Acta. Derm. Venereol.

      Volume: 95 Pages: 902-902

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] Orphan receptor GPR83 mediates pruriceptive processing in the spinal cord.2015

    • Author(s)
      Naono-Nakayama R., Funahashi H., Nishimori T, Takamiya K.
    • Journal Title

      Acta. Derm. Venereol.

      Volume: 95 Pages: 903-903

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Hemokinin-1-derived peptides have antipruritic effects in rats.2015

    • Author(s)
      H. Funahashi, R.Naono-Nakayama, G. Koganemaru, Y. Miyahara, T. Nishimori, K. Takamiya, Y. Ishida
    • Journal Title

      Therapeutic Targets for Neurological Diseases

      Volume: 2 Pages: 1-4

    • DOI

      10.14800/ttnd.704

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hemokinin-1 mediates pruriceptive processing in the rat spinal cord.2014

    • Author(s)
      H. Funahashi, R.Naono-Nakayama, K. Ebihara, G. Koganemaru, A. Kuramashi, T. Ikeda,T. Nishimori, Y. Ishida
    • Journal Title

      Neuroscience

      Volume: 277 Pages: 206-216

    • DOI

      10.1016/j.neuroscience.2014.07.001

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] An amino-terminal fragment of hemokinin-1 has an inhibitory effect on pruritic processing in rats.2014

    • Author(s)
      R.Naono-Nakayama, T. Ikeda, O.Matsushima, H.Sameshima, K. Takamiya, H.Funahashi, T. Nishimori
    • Journal Title

      Neuroscience

      Volume: 259 Pages: 172-183

    • DOI

      10.1016/j.neuroscience.2013.10.070

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 脊髄におけるオーファン受容体GPR83は痒み伝達機構に関与する2015

    • Author(s)
      中山-直野留美、船橋英樹、西森利數、高宮考悟
    • Organizer
      第42回日本脳科学会
    • Place of Presentation
      ANAホリデイ・インリゾート宮崎(宮崎県宮崎市)
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] ラットの三叉神経節および三叉神経感覚核におけるサブスタンスPおよびヘモキニン-1の分布2015

    • Author(s)
      井川加織、西森利數、船橋英樹、宮原裕、松尾寿栄、石田康
    • Organizer
      第42回日本脳科学会
    • Place of Presentation
      ANAホリデイ・インリゾート宮崎(宮崎県宮崎市
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] [Leu11]-HK-1-derived peptides with D-Trp have longer antipruriceptive effects in rats2015

    • Author(s)
      H. Funahashi, R. Naono-Nakayama, Y. Miyahara, Y. Ishida, T. Nishimori
    • Organizer
      45th Annual Meeting Society for Neuroscience
    • Place of Presentation
      Chicago
    • Year and Date
      2015-10-17 – 2015-10-21
    • Related Report
      2014 Research-status Report
  • [Presentation] [Leu11]-HK-1-derived peptides with D-Trp have longer antipruriceptive effects in rats2015

    • Author(s)
      Funahashi H., Naono-Nakayama R., Miyahara Y., Ishida Y., Nishimori T.
    • Organizer
      45th Annual Meeting Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] [Leu11]-HK-1-derived peptides with D-Trp prolong antipruriceptive effects in rats.2015

    • Author(s)
      Funahashi H, Naono-Nakayama R, Miyahara Y, Ishida Y, Nishimori T.
    • Organizer
      8th World Congress on Itch
    • Place of Presentation
      Nara Kasugano International Forum IRAKA(Nara, Japan)
    • Year and Date
      2015-09-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Orphan receptor GPR83 mediates pruriceptive processing in the spinal cord.2015

    • Author(s)
      Naono-Nakayama R, Funahashi H, Nishimori T, Takamiya K.
    • Organizer
      8th World Congress on Itch
    • Place of Presentation
      Nara Kasugano International Forum IRAKA(Nara, Japan)
    • Year and Date
      2015-09-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hemokinin-1 mediates pruriceptive processing in the rat spinal cord.2014

    • Author(s)
      Funahashi H, Naono-Nakayama R, Abe H, Ebihara K, Nishimori T, Ishida Y.
    • Organizer
      44th Annual Meeting Society for Neuroscience
    • Place of Presentation
      Washington D.C.
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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