Regulation of PirB, a functional receptor for axonal growth inhibitors, by LOTUS
| Project/Area Number |
26870480
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
Neurochemistry/Neuropharmacology
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| Research Institution | Yokohama City University |
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Principal Investigator |
KURIHARA Yuji 横浜市立大学, 生命医科学研究科, 特任助教 (00634552)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 神経科学 / 神経再生阻害因子 / アンタゴニスト / 神経再生 |
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| Outline of Final Research Achievements |
I analyzed the molecular and physiological function of LOTUS to paired immunoglobulin-like receptor B (PirB) which restricts functional recovery after damages to the central nervous system. I found that LOTUS interacted with PirB. LOTUS overexpressed with PirB in COS7 cells blocked the binding to PirB of Nogo, which is a functional ligand for PirB. Soluble form of LOTUS inhibited Nogo-induced growth cone collapse in cultured dorsal root ganglion neurons and Nogo-induced nerite outgrowth inhibition in cultured cerebellar granule neurons from ngr1-deficient mice. These data suggest that LOTUS functions as an antagonist for PirB.
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Report
(3 results)
Research Products
(4 results)
