| Project/Area Number |
26870496
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General anatomy (including histology/embryology)
Nerve anatomy/Neuropathology
|
|---|
| Research Institution | Okayama University (2015)
Kyoto Prefectural University of Medicine (2014) |
|---|
Principal Investigator |
Takanami Keiko 岡山大学, 自然科学研究科, 日本学術振興会特別研究員(RPD) (70578830)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 痒み / 神経回路 / GRP / 超高圧電子顕微鏡 / 三次元電子顕微鏡 / 連続ブロック表面走査型電子顕微鏡 / SBF-SEM / 重金属ブロック染色法 / ＧＲＰ / 神経解剖学 |
|---|
| Outline of Final Research Achievements |
Elucidation of the itch specific transmission mechanism advances rapidly since gastrin-releasing peptide receptor (GRPR) has been discovered as a first itch specific mediator recently. We focused on the GRPR ligand, gastrin-releasing peptide (GRP), as a funcutional molecule of itch transmission and analyzed the hierarchical morphological analysis of itch transmission nerve terminals using light microscopy and various advanced electron microscope technique. As a result, the visualization of three-dimensional itch transmission synaptic structure succeeded at an ultrastructural level.
|
