Analysis of the itch specific neural network from the spinal cord to the brain
| Project/Area Number |
26870496
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including histology/embryology)
Nerve anatomy/Neuropathology
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| Research Institution | Okayama University (2015)
Kyoto Prefectural University of Medicine (2014) |
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Principal Investigator |
Takanami Keiko 岡山大学, 自然科学研究科, 日本学術振興会特別研究員(RPD) (70578830)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 痒み / 神経回路 / GRP / 超高圧電子顕微鏡 / 三次元電子顕微鏡 / 連続ブロック表面走査型電子顕微鏡 / SBF-SEM / 重金属ブロック染色法 / ＧＲＰ / 神経解剖学 |
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| Outline of Final Research Achievements |
Elucidation of the itch specific transmission mechanism advances rapidly since gastrin-releasing peptide receptor (GRPR) has been discovered as a first itch specific mediator recently. We focused on the GRPR ligand, gastrin-releasing peptide (GRP), as a funcutional molecule of itch transmission and analyzed the hierarchical morphological analysis of itch transmission nerve terminals using light microscopy and various advanced electron microscope technique. As a result, the visualization of three-dimensional itch transmission synaptic structure succeeded at an ultrastructural level.
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Report
(3 results)
Research Products
(35 results)
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[Journal Article] Postnatal development of the gastrin-releasing peptide system in the lumbosacral spinal cord controlling male reproductive function in rats2016
Author(s)
Katayama, N., Oti, T., Takanami, K., Sakamoto, T., Sakamoto, H.
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Journal Title
Proceedings of the Japan Academy, Series B
Volume: 92
Issue: 2
Pages: 69-75
DOI
NAID
ISSN
0386-2208, 1349-2896
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 形態学解析から考える痒みの伝達機構2016
Author(s)
高浪景子，松田賢一，河田光博，坂本竜哉，坂本浩隆
Organizer
第121回日本解剖学会総会・全国学術集会
Place of Presentation
ビッグパレット福島（福島県郡山市）
Year and Date
2016-03-28
Related Report
Invited
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