| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
This study was aimed to clarify the relationship between osteoblastic RANKL expression and lectin-like oxidized LDL receptor-1 (LOX-1) in inflammatory bone destruction. I found that the RANKL expression in the inflamed bones was dependent on LOX-1 that was expressed in osteoblasts. In the co-culture of LOX-1-deleted osteoblasts and wild-type osteoclast precursors, the osteoclastogenesis induced by interleukin-1b and prostaglandin E2 decreased; this process occurred in parallel with the downregulation of osteoblastic RANKL expression. These results indicate that LOX-1-dependent osteoblastic RANKL expression in response to inflammation in bones promote osteoclast formation and bone resorption, suggesting that the blockage of LOX-1 could be a therapeutic target for inflammatory bone disease.
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