| Project/Area Number |
26870584
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Respiratory organ internal medicine
Applied pharmacology
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 肺胞上皮細胞 / OATP4C1 / EMT / 肺線維化 / メトトレキサート / 薬剤性肺障害 / 薬物トランスポーター / 細胞障害 / バイオマーカー |
|---|
| Outline of Final Research Achievements |
Our present study revealed that, at least in part, intracellular accumulation of MTX in alveolar epithelial cells via organic anion transporting polypeptide 4C1 (OATP4C1) resulted in the induction of pulmonary fibrosis in OATP4C1 knockdown mice. Additionally, we found that changing from alveolar cells to myofibroblast through EMT also resulted in the induction of pulmonary fibrosis. Thus, our results suggest that both EMT and OATP4C1 are important determinants for causing MTX-induced pulmonary fibrosis.
|
