Role of Androgen Receptor in Breast Cancer

• Project/Area Number: 26870597
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor diagnostics; Tumor therapeutics
• Research Institution: Tokai University
• Principal Investigator: NIIKURA Naoki 東海大学, 医学部, 講師 (60459469)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 乳癌 / アンドロゲンレセプター / トリプルネガティブ / エストロゲンレセプター

Outline of Final Research Achievements

Our study investigate compare the frequency of Androgen receptor (AR) expression in Estrogen Receptor (ER), PgR, ki-67 and subgroups and compare survival in tumor with high expression of AR and low expression in each subgroup to use microarray database.
Our data showed AR was significantly positive correlation ER. AR high expression is good prognostic factor in ER positive breast cancer. However AR high expression is poor prognostic factor in Triple negative breast cancer.

Research Products

• [Journal Article] Diagnostic performance of 18F-fluorodeoxyglucose PET/CT and bone scintigraphy in breast cancer patients with suspected bone metastasis (2016)
  • Author(s): Naoki Niikura Jun Hashimoto Toshiki Kazama Jun Koizumi Rin Ogiya Mayako Terao
  • Journal Title: Breast Cancer Volume: 23(1) Pages: 92-100
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Changes in tumor expression of HER2 and hormone receptors status after neoadjuvant chemotherapy in 21 755 patients from the Japanese breast cancer registry (2016)
  • Author(s): Niikura N, Sakatani T, Arima N, Ohi Y, Honma N, Kanomata N, Yoshida K, Kadoya T, Tamaki K, Kumaki N et al:
  • Journal Title: Annals of oncology Volume: 27(3) Issue: 3 Pages: 480-487
  • DOI: 10.1093/annonc/mdv611
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic factors of HER2-positive breast cancer patients who develop brain metastasis: a multicenter retrospective analysis. (2015)
  • Author(s): Hayashi N, Niikura N, Masuda N, Takashima S, Nakamura R, Watanabe K, Kanbayashi C, Ishida M, Hozumi Y, Tsuneizumi M, Kondo N, Naito Y, Honda Y, Matsui A, Fujisawa T, Oshitanai R, Yasojima H, Yamauchi H, Saji S, Iwata H.
  • Journal Title: Breast Cancer Res Treat Volume: 149(1) Issue: 1 Pages: 277-84
  • DOI: 10.1007/s10549-014-3237-7
  • Peer Reviewed
• [Journal Article] Clinical characteristics and outcome of bone-only metastasis in inflammatory and noninflammatory breast cancers. (2015)
  • Author(s): Kai M, Kogawa T, Liu DD, Fouad TM, Kai K, Niikura N, Hsu L, Willey JS, Theriault RL, Valero V, Ueno NT.
  • Journal Title: Clin Breast Cancer Volume: 15(1) Issue: 1 Pages: 37-42
  • DOI: 10.1016/j.clbc.2014.06.007
  • Peer Reviewed
• [Journal Article] Brain metastases in breast cancer (2014)
  • Author(s): Niikura Niikura, Saji S, Tokuda Y, Iwata H.
  • Journal Title: Jpn J Clin Oncol Volume: 44(12) Issue: 12 Pages: 1133-40
  • DOI: 10.1093/jjco/hyu156
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Reverse-phase protein array for prediction of patients at low risk of developing bone metastasis from breast cancer. (2014)
  • Author(s): Hayashi N, Manyam GC, Gonzalez-Angulo AM, Niikura N, Yamauchi H, Nakamura S, Hortobágyi GN, Baggerly KA, Ueno NT.
  • Journal Title: Oncologist. Volume: 19(9) Issue: 9 Pages: 909-14
  • DOI: 10.1634/theoncologist.2014-0099
  • Peer Reviewed
• [Journal Article] Treatment outcomes and prognostic factors for patients with brain metastases from breast cancer of each subtype: a multicenter retrospective analysis. (2014)
  • Author(s): Niikura N, Hayashi N, Masuda N, Takashima S, Nakamura R, Watanabe K, Kanbayashi C, Ishida M, Hozumi Y, Tsuneizumi M, Kondo N, Naito Y, Honda Y, Matsui A, Fujisawa T, Oshitanai R, Yasojima H, Tokuda Y, Saji S, Iwata H.
  • Journal Title: Breast Cancer Res Treat Volume: 147(1) Issue: 1 Pages: 103-12
  • DOI: 10.1007/s10549-014-3090-8
  • Peer Reviewed
• [Presentation] 乳癌組織におけるアンドロゲン受容体発現；エストロゲン受容体とKi-67 発現との関係 (2015)
  • Author(s): 寺尾 まやこ、 新倉直樹
  • Organizer: 日本臨床腫瘍学会
  • Place of Presentation: ロイトン札幌 （北海道札幌市）
  • Year and Date: 2015-07-16
• [Presentation] 乳癌におけるアンドロゲンレセプター発現と予後との関係 (2014)
  • Author(s): 新倉直樹１）、岩本高行2）、林直輝3）、徳田裕1）
  • Organizer: 日本外科学会
  • Place of Presentation: 京都
  • Year and Date: 2014-04-03 – 2014-04-05