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in vitro BBB reconstruction based on controlling engineered 4D microenvironment

Research Project

Project/Area Number 26870904
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Nano/Microsystems
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

Yanagawa Fumiki  国立研究開発法人産業技術総合研究所, 創薬基盤研究部門, 産総研特別研究員 (50645877)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords創薬スクリーニング / バイオMEMS / マイクロプロセス工学 / 三次元培養 / 灌流培養
Outline of Final Research Achievements

To fabricate microengineered platforms for cell culturing, photocleavable crosslinkers (NHS-PC-4armPEG and DBCO-PC-4armPEG) were developed. The characterization of cell behavior on photodegradable hydrogels, which were composed of the photocleavable crosslinkers, was investigated. The culture was performed without any cell damages. Also, the microengineerd devices were fabricated using photolithography techniques to perform 3D perfusion culture. The perfusion culture was also achieved using the fabricated microdevice, To commercialize the microdevices, they would need to be redesigned to evaluate the biological function of micro-engineered tissue.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2015 2014

All Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Presentation] 3D perfusion culture through patterned photodegradable hydrogels2015

    • Author(s)
      Fumiki Yanagawa, Masato Tamura, Shinji Sugiura, Toshiyuki Takagi, Kimio Sumaru, Toshiyuki Kanamori
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Micropatterning of click-crosslinked and photodegradable hydrogels for 3D perfusion culture2015

    • Author(s)
      Fumiki Yanagawa, Masato Tamura, Shinji Sugiura, Toshiyuki Takagi, Kazumi Shin, Kimio Sumaru, Toshiyuki Kanamori
    • Organizer
      MIcroTAS 2015
    • Place of Presentation
      Gyeongju, KOREA
    • Year and Date
      2015-10-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preparation of photodegradable hydrogels using activated-ester-type photocleavable crosslinker2014

    • Author(s)
      Fumiki Yanagawa, Shinji Sugiura, Toshiyuki Takagi, Kimio Sumaru, Toshiyuki Kanamori
    • Organizer
      The 10th SPSJ International Polymer Conference (IPC 2014)
    • Place of Presentation
      エポカルつくば(茨城県)
    • Year and Date
      2014-12-02 – 2014-12-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Activated-ester-type photocleavable crosslinker for preparing micropatterned photodegradable hydrogel2014

    • Author(s)
      Fumiki Yanagawa, Shinji Sugiura, Toshiyuki Takagi, Kimio Sumaru, Toshiyuki Kanamori
    • Organizer
      The 22nd Polymer Networks Group Meeting (PNG) and the 10th Gel Symposium sponsored by Institute for Solid State Physics (PN&G 2014)
    • Place of Presentation
      東京大学(東京都)
    • Year and Date
      2014-11-10 – 2014-11-14
    • Related Report
      2014 Research-status Report
  • [Presentation] Characterization of cell behavior on patterned photodegrable hydrogels2014

    • Author(s)
      Fumiki Yanagawa, Shinji Sugiura, Toshiyuki Takagi, Kimio Sumaru, Toshiyuki Kanamori
    • Organizer
      MicroTAS 2014
    • Place of Presentation
      Gonzalez Convention Center (San Antonio, Texas, USA)
    • Year and Date
      2014-10-26 – 2014-10-30
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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