Role of beta-Klotho in regulating fetal growth and body weight in mice
Project/Area Number |
26870926
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Food science
Eating habits
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Research Institution | Foundation for Biomedical Research and Innovation |
Principal Investigator |
Kobayashi Kanako 公益財団法人先端医療振興財団, その他部局等, 研究員 (10724106)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | β-Klotho / 子宮内胎児発育遅延 / 卵黄嚢 / 分子生物学 / ノックアウトマウス |
Outline of Final Research Achievements |
The aim of this study is to elucidate the molecular mechanism underlying fetal growth restriction and reduced body weight in β-klotho knockout (KO) mice. Since an embryo absorbs maternal nutrients through its yolk sac before placental maturation, we hypothesized that β-Klotho expressed in the yolk sac plays a key role in supplying maternal nutrients to the embryo. We found that β-klotho mRNA was predominantly expressed in the yolk sac endoderm cells, the primary site of nutrient absorption. RNA-sequencing analysis revealed that the gene expression levels of the metabolic enzymes and the nutrient transporters were altered in the KO yolk sac. These results suggest that β-Klotho in yolk sac contributes to the regulation of fetal growth through modulating the expression levels of genes involved in nutrient metabolism.
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Report
(3 results)
Research Products
(1 results)
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[Journal Article] Hepatocyte β-Klotho regulates lipid homeostasis but not body weight in mice.2016
Author(s)
Kobayashi K, Tanaka T, Okada S, Morimoto Y, Matsumura S, Manio MC, Inoue K, Kimura K, Yagi T, Saito Y, Fushiki T, Inoue H, Matsumoto M, Nabeshima Y.
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Journal Title
FASEB J.
Volume: 30
Issue: 2
Pages: 849-62
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research