| Project/Area Number |
26882022
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
Nomoto Takahiro 東京工業大学, 資源化学研究所, 助教 (00734732)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 高分子ミセル / 光増感剤 / ドラッグデリバリー / 光線力学療法 / 高分子 |
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| Outline of Final Research Achievements |
This study was aimed at the development of a novel polymeric nanocarrier that can deliver photosensitizer selectively into tumor-associated macrophages. For this purpose, we constructed a polymeric micelle composed of the amphiphilic copolymer that has a hydrophilic poly(ethylene glycol) and a hydrophobic poly(aspartic acid) derivative, and encapsulated photosensitizers into the core of the micelle. The surface of the photosensitizer-loaded micelle was further modified with the peptides targeting tumor-associated macrophages. In vivo study revealed that the micelle delivered the photosensitizer efficiently to macrophages in the tumor after systemic administration to the mouse bearing a subcutaneous tumor. The peptide conjugated-micelle may offer a promising platform to develop macrophage-targeting drug delivery systems.
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