Development of functional polymers to hijack tumor-associated macrophages

• Project/Area Number: 26882022
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: Nomoto Takahiro 東京工業大学, 資源化学研究所, 助教 (00734732)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 高分子ミセル / 光増感剤 / ドラッグデリバリー / 光線力学療法 / 高分子

Outline of Final Research Achievements

This study was aimed at the development of a novel polymeric nanocarrier that can deliver photosensitizer selectively into tumor-associated macrophages. For this purpose, we constructed a polymeric micelle composed of the amphiphilic copolymer that has a hydrophilic poly(ethylene glycol) and a hydrophobic poly(aspartic acid) derivative, and encapsulated photosensitizers into the core of the micelle. The surface of the photosensitizer-loaded micelle was further modified with the peptides targeting tumor-associated macrophages. In vivo study revealed that the micelle delivered the photosensitizer efficiently to macrophages in the tumor after systemic administration to the mouse bearing a subcutaneous tumor. The peptide conjugated-micelle may offer a promising platform to develop macrophage-targeting drug delivery systems.

Research Products

• [Journal Article] Calcium phosphate-based organic-inorganic hybrid nanocarriers with pH-responsive on/off switch for photodynamic therapy (2016)
  • Author(s): T. Nomoto, S. Fukushima, M. Kumagai, K. Miyazaki, A. Inoue, P. Mi, Y. Maeda, K. Toh, Y. Matsumoto, Y. Morimoto, A. Kishimura, N. Nishiyama, K. Kataoka
  • Journal Title: Biomater. Sci. Volume: 印刷中 Issue: 5 Pages: 826-838
  • DOI: 10.1039/c6bm00011h
  • Peer Reviewed
• [Presentation] 光応答性有機無機ハイブリッドナノメディシン (2016)
  • Author(s): 野本貴大
  • Organizer: 第18回次世代医工学研究会
  • Place of Presentation: 東京
  • Year and Date: 2016-01-29
• [Presentation] 全身投与後の光選択的遺伝子導入を可能とする三層構造高分子ミセル (2016)
  • Author(s): 野本貴大、福島重人、熊谷康顕、町谷香織、松本有、大庭誠、長田健介、西山伸宏、片岡一則
  • Organizer: 第25回インテリジェント材料・システムシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2016-01-08
• [Presentation] Three-layered polyplex micelle for light-induced gene transfer (2015)
  • Author(s): T. Nomoto, S. Fukushima, M. Kumagai, K. Machitani, Y. Matsumoto, M. Oba, K. Miyata, K. Osada, N. Nishiyama, K. Kataoka
  • Organizer: The 13th US-Japan Symposium on Drug Delivery Systems
  • Place of Presentation: Lahaina, Maui, Hawaii, USA
  • Year and Date: 2015-12-18
  • Int'l Joint Research