Functional recovery through plastic changes after spinal cord injury in primates

• Project/Area Number: 26882025
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kyoto University
• Principal Investigator: NAKAGAWA HIROSHI 京都大学, 霊長類研究所, 研究員 (10732901)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 脊髄損傷 / 運動ニューロン / 神経可塑性 / 可塑性

Outline of Final Research Achievements

After the central nervous system (CNS) injury, motor functions are often recovered with natural course. It is known as to contribute to neuroplasticity. In this study, we investigated the relationship between recovery of motor functions and neural plasticity (neural circuits and spine of motoneuron). We found that motor functions were gradually recovered in conjunction with remodeling of neural circuits with natural course after spinal cord injury. This finding may contribute to develop therapy of CNS injury.

Research Products

• [Journal Article] Reorganization of corticospinal tract fibers after spinal cord injury in adult macaques. (2015)
  • Author(s): Nakagawa H, Ninomiya T, Yamashita T, Takada M
  • Journal Title: Sci Rep Volume: 5 Issue: 1 Pages: 11986-11986
  • DOI: 10.1038/srep11986
  • NAID: 120005758238
  • Peer Reviewed / Open Access
• [Presentation] The pattern of reinnervation of sprouting corticospinal tract fibers after spinal cord injury in macaques. (2015)
  • Author(s): Nakagawa, H., Ninomiya, T., Yamashita, T. and Takada, M.
  • Organizer: Society for Neuroscience 2015
  • Place of Presentation: Chicago
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] Reinnervation of corticospinal tract fibers after spinal cord injury in macaques (2015)
  • Author(s): Nakagawa, H., Ninomiya, T., Yamashita, T. and Takada, M.
  • Organizer: 第３８回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-07-28
• [Presentation] Reorganization of corticospinal tract fibers after spinal cord injury in macaques. (2015)
  • Author(s): Nakagawa, H., Ninomiya, T., Yamashita, T. and Takada, M.
  • Organizer: The 50 the Japanese Physical Therapy Association
  • Place of Presentation: Tokyo
  • Year and Date: 2015-06-05
• [Presentation] Contribution of RGMa inhibition to recovery of motor functions after spinal cord injury in macaques (2015)
  • Author(s): Nakagawa H., Ninomiya T., Yamashita T., Takada M
  • Organizer: Eleventh Gottingen Meeting of the German Neuroscience Society
  • Place of Presentation: Gottingen University
  • Year and Date: 2015-03-18 – 2015-03-21
• [Remarks] 京都大学霊長類研究所 統合脳システム分野
  • URL: http://www.pri.kyoto-u.ac.jp/sections/systems_neuroscience/index.html