| Project/Area Number |
26890011
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Tanaka Daisuke 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (90456921)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 情動 / 感情 / 味覚 / c-fos / 終脳 / 神経活動 / 快情動 / 不快情動 / 側坐核 / 腹側淡蒼球 / 拡張扁桃体 |
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| Outline of Final Research Achievements |
The positive and negative affects are reflected in behavioral “liking” and ”disgust” taste reactions, respectively. The neural activities of individual neurons in the ventral telencephalon responding different taste stimuli are poorly understood. We performed taste reactivity test using different taste stimuli and analyzed the expression of c-fos, a molecular marker representing activated neurons, in the ventral telencephalon. Unexpectedly, the ratio of c-fos-positive cells to total cells was significantly higher in the ventral telencephalon with bitter taste stimuli that induces “disgust” reactions, compared to water control. These findings indicated that some population of neurons in the ventral telencephalon were excited by bitter taste stimuli and may encode “disgust” reactions. Identification and characterization of neurons underlying “disgust” reactions would be the first step to understand the neural mechanism of negative affect.
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